Results 91 to 100 of about 16,122 (287)

Managing Myelofibrosis: Matching Advances in Treatments With Clinical Unmet Needs

Hematological Oncology, Volume 43, Issue S1, March 2025.
ABSTRACT Myelofibrosis (MF) is characterized by anemia, constitutional symptoms, hepatosplenomegaly and bone marrow fibrosis, and is associated with poor survival. The janus kinase inhibitor (JAKi) ruxolitinib has been the mainstay of treatment for over a decade.
Tze Wei Chan, Hein Than, Feng‐Ju Huang, Gauri Billa, Lai Heng Lee   +4 more
wiley   +1 more source

Consensus statement on the diagnosis, management, and treatment of angioedema mediated by Bradykinin. Part. II: treatment, follow-up, and special situations [PDF]

, 2011
Background: There are no previous Spanish guidelines or consensus statements on bradykinin-induced angioedema. Aim: To draft a consensus statement on the management and treatment of angioedema mediated by bradykinin in light of currently available ...
Baeza, M. L., Caballero, T., Cabañas, R., Campos, A., Cimbollek, S., González-Quevedo, T., Guilarte, M., Gómez-Traseira, C., Jurado-Palomo, J., Larco, J. I., López-Serrano, M. C., López-Trascasa, Margarita, Marcos, C., Muñoz- Caro, J. M., Pedrosa, M., Prior, N., Rubio, M., Sala-Cunill, A.   +17 more
core   +1 more source

The metabolism of anabolic-androgenic steroids in the greyhound

, 2013
BACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity.
Ambrus, Joseph I., Cawley, Adam T., Cunnington, Karen, Kerwick, Carmel M., McKinney, Andrew R, McLeod, Malcolm D., Stewart, Rhiannon T., Willis, Anthony C., Young, E. Bruce   +8 more
core   +1 more source

Chronic pelvic pain among transgender men and gender diverse adults assigned female at birth

Andrology, Volume 13, Issue 3, Page 600-609, March 2025.
Abstract Background There are limited data on pelvic pain among transgender men and gender diverse people, and the impact of testosterone on pelvic pain is poorly understood. Objective Characterize the prevalence and correlates of chronic pelvic pain (CPP) among transgender men and gender diverse people and examine the association between testosterone ...
Diana M. Tordoff, Mitchell R. Lunn, Annesa Flentje, Diana Atashroo, Bertha Chen, Zubin Dastur, Micah E. Lubensky, Matthew Capriotti, Juno Obedin‐Maliver   +8 more
wiley   +1 more source

Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia

Case Reports in Hematology, 2019
Diamond-Blackfan anaemia (DBA) is a rare congenital red cell aplasia that presents in infancy. The exact molecular mechanism of ineffective erythropoiesis and red cell aplasia remains unclear, rendering targeted therapy elusive. The mainstay treatment of
Kern Y. Chai, Cara J. Quijano, Shingirai Chiruka   +2 more
doaj   +1 more source

Púrpura trombopénica inmune : múltiples tratamientos para una enfermedad [PDF]

, 2012
En el present treball es descriuen les principals característiques clíniques de la purpura trombopènica immune, com ara, la distribució per sexes, edat, la presència d'hemorràgies en el moment del diagnòstic i la seva gravetat, la xifra de plaquetes i la
Lluch García, Rafael, Pujol Moix, Nuria, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +3 more
core  

Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review

European Journal of Haematology, Volume 114, Issue 3, Page 458-468, March 2025.
ABSTRACT Objectives Evidence‐based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP. Methods We included all study designs and extracted data in aggregate or individually for patients who received one or more ...
Saifur R. Chowdhury, Emily Sirotich, Gordon Guyatt, Daya Gill, Dimpy Modi, Laura M. Venier, Syed Mahamad, Mahmudur Rahman Chowdhury, Kerolos Eisa, Carolyn E. Beck, Vicky R. Breakey, Kerstin de Wit, Stephen Porter, Kathryn E. Webert, Adam Cuker, Clare O'Connor, Jennifer MacWhirter ‐DiRaimo, Justin W. Yan, Charles Manski, John G. Kelton, Matthew Kang, Gail Strachan, Ziauddin Hassan, Barbara Pruitt, Menaka Pai, Rachael F. Grace, Dale Paynter, Jay Charness, Nichola Cooper, Steven Fein, Arnav Agarwal, Hasmik Nazaryan, Ishaq Siddiqui, Russell Leong, Sushmitha Pallapothu, Aaron Wen, Emily Xu, Bonnie Liu, Amirmohammad Shafiee, Preksha Rathod, Henry Kwon, Jared Dookie, Dena Zeraatkar, Lehana Thabane, Rachel Couban, Donald M. Arnold   +45 more
wiley   +1 more source

Danazol induces apoptosis and cytotoxicity of leukemic cells alone and in combination with purine nucleoside analogs in chronic lymphocytic leukemia

Annals of Hematology, 2015
Recently, great progress has been achieved in the treatment of chronic lymphocytic leukemia (CLL). However, some patients, particularly older patients with comorbidities or with relapsed/refractory leukemia, still have limited therapeutic options.
M. Podhorecka, Arkadiusz Macheta, S. Chocholska, A. Bojarska-Junak, A. Szymczyk, A. Gorący, A. Dmoszyńska, M. Hus   +7 more
semanticscholar   +1 more source

Medisinsk behandling av endometriose [PDF]

, 2008
Endometriose defineres i korte trekk som endometrievev utenfor livmorhulen. Det er en vanlig, kronisk sykdom som hovedsaklig forårsaker smertesymptomer som dysmenoré, dyspareuni og ikke-menstruelle smerter. Men endometriose kan også redusere fertiliteten
Kvalbein-Olsen, Lars Christian
core  

Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability.

Molecular Pharmaceutics, 2013
Cocrystals have become an established and adopted approach for creating crystalline solids with improved physical properties, but incorporating cocrystals into enabling pre-clinical formulations suitable for animal dosing has received limited attention ...
S. Childs, P. Kandi, Sreenivas R. Lingireddy   +2 more
semanticscholar   +1 more source