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Danazol in the Treatment of Gynaecomastia [PDF]

open access: possibleDrugs, 1980
Gynaecomastia develops in association with a variety of underlying factors. Many cases are mild in degree and of short duration and do not require treatment. However, quite severe and painful gynaecomastia can occur. In such cases treatment with danazol can lead to a marked reduction in size and a lessening of pain and tenderness of the breasts. In 60 %
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Danazol in the Treatment of Menorrhagia [PDF]

open access: possibleDrugs, 1980
The most commonly used medical therapies for the treatment of menorrhagia have been progestogens alone or combined with an oestrogen, and antifibrinolytic drugs. Most recently, prostaglandin synthetase inhibitors have been shown to reduce menstrual blood loss in some women.
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Post Danazol Amenorrhoea

Obstetrical & Gynecological Survey, 1984
Four women out of 242 experienced amenorrhoea in excess of 6 months duration following danazol treatment. Two of these exhibited an unusual monotropic rise of FSH into the post menopausal range for 4-5 months following the end of therapy. This was associated with an excessive response to GnRH injection.
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Danazol for unexplained subfertility

Cochrane Database of Systematic Reviews, 2007
The synthetic androgen Danazol, was developed in the 1970's as a treatment for endometriosis. Its use was soon advocated in women with unexplained subfertility. Two randomised trials were subsequently conducted to assess the effectiveness of danazol in this population.The objective of this review was to assess the effect of danazol on live birth rate ...
E, Hughes   +3 more
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Evaluation of danazol therapy for patients with PiZZ alpha-1-antitrypsin deficiency.

American Review of Respiratory Disease, 2015
An inherited deficiency of alpha 1-antitrypsin with blood concentrations less than 80 mg/dl is associated with the accelerated development of emphysema.
M. Wewers   +4 more
semanticscholar   +1 more source

Danazol Inhibits Steroidogenesis

Fertility and Sterility, 1977
Danazol was found to inhibit multiple enzymes of steroidogenesis directly in the pregnant mare serum (PMS)-treated hamster ovary and the rat testis and adrenal in vitro. In the PMS-treated hamster ovary, danazol inhibited 17alpha-hydroxylase, 17,20-lyase, and 3beta-hydroxysteroid dehydrogenase.
Kenneth J. Ryan   +5 more
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A Study of Danazol's Safety

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1995
In a review of medical records of 530 recipients of danazol at Group Health Cooperative of Puget Sound, we identified 154 (29%) people who reported at least one adverse event that occurred within 45 days after receiving the drug. In no patient did the event require hospitalization, and there were no known long‐term sequelae.
Marian Wald Myers, Susan S. Jick
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Analytical Method Development and Validation of a Stability-Indicating RP-HPLC Method for the Analysis of Danazol in Pharmaceutical Dosage Form

, 2016
Danazol is an endocrine metabolic agent or anti gonadotropin drug. The aim of this study was to develop a accurate, specific, linear, simple, rapid, precise, reliable and stability indicating RP-HPLC analytical method for the determination of Danazol in ...
A. Kirthi   +6 more
semanticscholar   +1 more source

Microbial Transformation of Danazol

Natural Product Letters, 2002
Danazol (17beta-hydroxy-17alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium lini, Aspergillus niger, and Cephalosporium aphidicola yielded 17beta-hydroxy-2-(hydroxymethyl)-17-alpha-pregn-4-en-20-yn-3-one (2) and 17beta-hydroxy-2-(hydroxymethyl)-17 alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with ...
Atta-ur-Rahman   +2 more
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Danazol in the Treatment of Infertility

Drugs, 1980
Danazol, an interesting pharmacologic steroid 'in search of a disease', was first used by my group in the management of endometriosis because of the marked anti-endometrial effects found during clinical trials. The results in alleviating dysmenorrhoea, dyspareunia, and pelvic discomfort were surprisingly good, but more important was the 40 to 50 ...
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