Results 1 to 10 of about 128 (107)
Recueil des Travaux Chimiques des Pays-Bas, 1971 AbstractA number of 19‐nor‐pregnane derivatives bearing a 17,20‐diene side‐chain has been synthesized; the stereochemistry of the products formed during the preparation of non‐substituted, mono‐ and dimethyl allenes has been studied by means of application of Brewster's Rules and NMR spectroscopy.
A. J. M. Weber +3 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Objective. We aimed to analyze the possible molecular mechanism of Xihuang pill (XHP) in the treatment of pancreatic cancer based on methods of network pharmacology, molecular docking, and bioinformatics. Methods. The main active components and targets were obtained through the TCMSP database, the BATMAN‐TCM database, and the Chemistry database.
Jing Wang +5 more
wiley +1 more source
THIN-LAYER CHROMATOGRAPHY OF SOME PREGNENES AND PREGNADIENES
The Journal of General and Applied Microbiology, 1974 The resolution of different steroids on a thin-layer plate with a large number of solvent systems was investigated. These steroids are of the pregnene models differing in the number and position of the double bond, and ketone and hydroxyl groups. The mobility of these steroids on the plate with the most suitable solvent systems (9 different systems ...
SALLAM, LOTFY A. R. +2 more
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Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements
BioMed Research International, Volume 2017, Issue 1, 2017., 2017 Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer.
Qingxi Yue +5 more
wiley +1 more source
Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton [PDF]
Chemistry Central Journal, 2010 A series of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton, namely 3β-benzoyloxy-4,16-pregnadiene-6,20-dione and 3β-furoyloxy-4,16-pregnadiene- 6,20-dione, which may be good inhibitors for the 5α-reductase enzyme and show high antiandrogenic activity, were synthesized starting from diosgenin.
Li Yijing, Li Hongqi, Li Juan
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Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac
The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014 Context. Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. Objective. Aceclofenac nanovesicles were made using guggul lipid for formulating stable transdermal formulation. Materials and Methods.
Praveen Kumar Gaur +4 more
wiley +1 more source
Solid Lipid Nanoparticles of Guggul Lipid as Drug Carrier for Transdermal Drug Delivery
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul lipid as major lipid component and analyzed for physical parameters, permeation profile, and anti‐inflammatory activity. The SLNs were prepared using melt‐emulsion sonication/low temperature‐solidification method and characterized for physical parameters, in vitro ...
Praveen Kumar Gaur +3 more
wiley +1 more source
Biosynthesis of 3β‐hydroxy‐5,7‐pregnadien‐20‐one by the horse fetal gonad
FEBS Letters, 1983 The production of equilin and the other ring B‐unsaturated estrogens by the pregnant mare is anomalous in that they are biosynthesised by a cholesterol‐independent pathway. Fetal horse gonads were incubated with tritiated sodium acetate and radiochemically pure 3β‐hydroxy‐5,7‐pregnadien‐20‐one and 3β‐hydroxy‐5,7‐androstadien‐17‐one were isolated.
Tait, A.D., Hodge, L.C., Allen, W.R.
openaire +2 more sources
Nuclear Receptors in Nonalcoholic Fatty Liver Disease
Journal of Lipids, Volume 2012, Issue 1, 2012., 2012 Nuclear receptors comprise a superfamily of ligand‐activated transcription factors that are involved in important aspects of hepatic physiology and pathophysiology. There are about 48 nuclear receptors in the human. These nuclear receptors are regulators of many hepatic processes including hepatic lipid and glucose metabolism, bile acid homeostasis ...
Jorge A. López-Velázquez +5 more
wiley +1 more source
Structural and synthetic investigations of South African marine natural products [PDF]
, 2000 A chemical investigation of six different marine invertebrates, collected along the South African coastline, resulted in the isolation and structural elucidation of fifteen previously undescribed secondary metabolites along with seven known compounds ...
Beukes, Denzil Ronwynne
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