Results 131 to 140 of about 642,992 (266)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Interscapular Freckling and Comedone-like Lesions in Neurofibromatosis Type 1 with Associated Intestinal Complications. [PDF]

Indian J Dermatol
Daniel SJ, Ganesh B, Desingh K.
europepmc   +1 more source

Learning Moisture‐Induced Damage From Vision: Diffusion Models for Real‐Time Monitoring of Additive Manufacturing Processes

Advanced Science, EarlyView.
We introduce a vision‐based real‐time monitoring system for additive manufacturing that detects subtle moisture‐induced degradation via a diffusion model‐based framework. The approach enables nondestructive assessment of moisture‐induced damage level and mechanical performance and establishes a practical route toward more intelligent, reliable, and ...
Jiyoung Jung, Yuna Yoo, Dharneedar Ravichandran, Dahyun Daniel Lim, Grace X. Gu   +4 more
wiley   +1 more source

PERFIL CLÍNICO E LABORATORIAL DOS CANDIDATOS À DOAÇÃO DE PLASMA CONVALESCENTE PARA TRATAMENTO DA COVID-19

Hematology, Transfusion and Cell Therapy, 2020
A.N.L. Prezotti, R.L.C.D. Amaral, S.S. Marcondes, J.S.M. Duarte, M.B. Silveira, D.O. Lyra, E.X. Morais, M.D.P.S.V. Orletti, D.M.D.C. Rocha, A.R. Neto   +9 more
doaj   +1 more source

Uncovering Illusions of Understanding: A Falsificationist Perspective. [PDF]

Comput Brain Behav
Heck DW.
europepmc   +1 more source

Bidirectional Disulfide Metathesis Enables Recycling of High‐Performance Thermoset Networks

Advanced Science, EarlyView.
A cyclic aromatic disulfide comonomer enables dual‐mode recyclable pDCPD thermosets through bidirectional disulfide metathesis. The resulting networks combine enhanced mechanical performance with thermal reprocessability and chemical depolymerization into reusable oligomeric fragments, allowing regeneration of high‐performance thermosets with minimal ...
Bohan Li, Jie Zheng, Daniel Paniroi Situmorang, Jia‐xin Neo, Hongzhi Feng, Jinling Li, Loh Xian‐Jun, Zibiao Li, Teck‐Peng Loh   +8 more
wiley   +1 more source

Hamaker Constants of van der Waals Materials under Clean‐Interface Conditions

Advanced Science, EarlyView.
Clean‐interface adhesion in representative van der Waals materials is quantified by Ultra High Vacuum (UHV) Atomic Force Microscopy (AFM) with in situ cleaning and calibrated probes. Benchmark Hamaker constants for graphene, MoS2, and SiO2 are established, while humidity is shown to reversibly amplify adhesion, explaining much of the scatter in ...
Daniel Gallego‐Fuente, Jaime Colchero, Julio Gomez‐Herrero, Pablo Ares   +3 more
wiley   +1 more source

Reply to Çınar, A. The Potential Role of Organ-to-Liver Ratios in Immune-Related FDG PET Imaging. Comment on "Panikar et al. Exploratory FDG PET/CT Imaging in mCRPC Patients Treated with Sipuleucel-T ± IL-7: A Phase II Trial Subanalysis. <i>Int. J. Mol. Sci.</i> 2026, <i>27</i>, 5129". [PDF]

Int J Mol Sci
Panikar SS, Bansal D, Crandall J, Raman H, Picus J, Ippolito JE, Thorek DLJ, Wahl RL, Pachynski RK.   +8 more
europepmc   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Toxicities of Fruquintinib in Gastrointestinal Malignancies: A Systematic Review and Meta-Analysis. [PDF]

Oncol Res
Jones DT, Sangha T, Manjikian A, Ghobrial M, Shawesh Q, Tiwana E, Hearn E, Latif A, Tupas E, Hanspal A, Nanda RK, Srinivasmurthy R, Ta J, Pandit M, Larson CAJ, Thein KZ.   +15 more
europepmc   +1 more source