Results 141 to 150 of about 616,210 (266)

Correction: How safe is teaching radical cystectomy? [PDF]

open access: yesWorld J Urol
Scherrer M   +15 more
europepmc   +1 more source

Extra Climate Benefits From Afforestation Due to Reduced Forest Fragmentation in China

open access: yesAdvanced Science, EarlyView.
Afforestation in China reduced forest fragmentation in 2015, transforming 51.8 M ha of edge forests into interior forests. This enhanced carbon sequestration (1.4±0.2 Pg CO2e, a cooling biogeochemical effect), while reduced albedo (−0.9 Pg CO2e, a warming biophysical effect) partially offset the gain, yielding a net extra climate benefit of ...
Nan Meng   +19 more
wiley   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

open access: yesAdvanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo   +4 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai   +12 more
wiley   +1 more source

Correction: Next‑Generation SCS Programming Platform: Enhancing ECAP Fidelity and Objectivity to Improve Patient Experience. [PDF]

open access: yesPain Ther
Parker DJ   +12 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

open access: yesAdvanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao   +19 more
wiley   +1 more source

Correction: Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans. [PDF]

open access: yesSci Rep
Ahmed S   +12 more
europepmc   +1 more source

Learning Moisture‐Induced Damage From Vision: Diffusion Models for Real‐Time Monitoring of Additive Manufacturing Processes

open access: yesAdvanced Science, EarlyView.
We introduce a vision‐based real‐time monitoring system for additive manufacturing that detects subtle moisture‐induced degradation via a diffusion model‐based framework. The approach enables nondestructive assessment of moisture‐induced damage level and mechanical performance and establishes a practical route toward more intelligent, reliable, and ...
Jiyoung Jung   +4 more
wiley   +1 more source

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