Results 31 to 40 of about 98,015 (286)

Age and heat stress as determinants of telomere length in a long-lived fish, the Siberian Sturgeon [PDF]

open access: yes, 2016
Telomeres shorten at each cell division due to the end-replication problem but also in response to oxidative stress. Consequently, telomeres shorten with age in many endotherms, and this shortening is accelerated under stressful environmental conditions.
Angelier, Frédéric   +3 more
core   +3 more sources

L'acétylcholinestérase des poissons, cible des organophosphorés et des carbamates. Caractérisation du gène et des formes moléculaires de l'enzyme chez Danio rerio. Effets des anticholinestérasiques

open access: yesKnowledge and Management of Aquatic Ecosystems, 1998
L'acétylcholinestérase (AChE, EC 3.1.1.7) est une enzyme indispensable de la transmission synaptique cholinergique. Son inhibition par les organophosphorés et les carbamates est à la base de certains traitements insecticides et nématicides utilisés en ...
BERTRAND C.   +4 more
doaj   +1 more source

The Zebrafish (Danio rerio) Is a Relevant Model for Studying Sex-Specific Effects of 17β-Estradiol in the Adult Heart [PDF]

open access: yes, 2019
Cardiovascular diseases are a major cause of morbidity and mortality, and there are significant sex differences therein. However, the underlying mechanisms are poorly understood.
Hassel, David   +2 more
core   +1 more source

Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics [PDF]

open access: yes, 2020
The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal ...
Jiang, Hui-Rong   +13 more
core   +2 more sources

Toxicity and neurotoxicity profiling of contaminated sediments from Gulf of Bothnia (Sweden): a multi-endpoint assay with Zebrafish embryos

open access: yesEnvironmental Sciences Europe, 2019
Background The toxicological characterization of sediments is an essential task to monitor the quality of aquatic environments. Many hazardous pollutants may accumulate in sediments and pose a risk to the aquatic community.
Riccardo Massei   +9 more
doaj   +1 more source

Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway [PDF]

open access: yes, 2016
open15Over 10 million people every year become infected by Treponema pallidum and develop syphilis, a disease with broad symptomatology that, due to the difficulty to eradicate the pathogen from the highly vascularized secondary sites of infection, is ...

core   +1 more source

Localization of α-synuclein in teleost central nervous system: immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp, Cyprinus carpio [PDF]

open access: yes, 2015
Alpha synuclein (α-syn) is a 140 amino acid vertebrate-specific protein, highly expressed in the human nervous system and abnormally accumulated in Parkinson's disease and other neurodegenerative disorders, known as synucleinopathies.
CASINI, Arianna   +6 more
core   +1 more source

Advances in Conductive Nanomaterials for Cardiac Arrhythmia and Future Directions in Bioevaluation Strategies

open access: yesAdvanced Healthcare Materials, EarlyView.
Conductive nanomaterials (CNMs) show promising potential in cardiac tissue regeneration and restoring cardiac rhythm as reported in several in vitro studies. This review article elaborates on the applications of CNMs in the treatment of myocardial infarction (MI) and MI‐induced cardiac arrhythmias, and it sheds light on the innovative approach of ...
Sumithra Y. Srinivasan, Anna Laromaine
wiley   +1 more source

Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model

open access: yesFrontiers in Immunology, 2018
DDX41 is an important sensor for host recognition of DNA viruses and initiation of nuclear factor-κB (NF-κB) and IFN signaling pathways in mammals. However, its occurrence and functions in other vertebrates remain poorly defined.
Jun-xia Ma   +7 more
doaj   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou   +13 more
wiley   +1 more source

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