Results 111 to 120 of about 96,898 (280)

Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration

Nature Communications
WNT signaling is an essential pathway regulating tissue morphogenesis and regeneration. However, harnessing the pathway for regenerative medicine has been challenging due to the lack of approaches to identify and deliver specific WNT ligands to the ...
Lingyan Yang, Shixiang Wang, Zhiping Qiao, Yue Liu, Xu Wang, Liying Liu, Chunfang Yang, Jiying Ding, Miao Lei, Jiayi Zheng, Wenxiang Hu, Ye-guang Chen, Yun-Shen Chan   +12 more
doaj   +1 more source

Bioethics and the World Order: A Curious Coincidence Between Chinese and African Approaches

Developing World Bioethics, EarlyView.
ABSTRACT The post‐1945 world order is standardly pictured as a Westphalian system, in which each state is equal under the law with sovereign authority over its territories. This paper argues that the Westphalian system is changing and examines the implications for bioethics. We show that cross‐border health, economic, ecologic, and sociopolitical risks
Nancy S. Jecker, Jing‐Bao Nie, Anita Ho   +2 more
wiley   +1 more source

New organizational forms: Deconstructing and reconfiguring the literature

European Management Review, EarlyView.
Abstract Less hierarchical, self‐managing, agile, alternative: so‐called “new organizational forms” draw interest from scholars and practitioners alike. Despite an abundance of both conceptual and empirical research, the “new organizational form” concept remains elusive, capturing a growing diversity of phenomena and labels.
Constantin Bremer
wiley   +1 more source

Decentralised Autonomous Organisation (DAO) Business Model

Annales Universitatis Mariae Curie-Skłodowska Sectio H, Oeconomia
Theoretical background: In general, authors claim that the business model for any human-beings organisation defines who and how creates values in a socio-economic context.
Małgorzata Pańkowska, Paweł Wyszomirski   +1 more
doaj   +1 more source

Mamba‐Based Deep Learning Model for Automated Periapical Index Classification Using Periapical Radiographs and Clinical Metadata

International Endodontic Journal, EarlyView.
ABSTRACT Aim Apical periodontitis (AP) diagnosis primarily relies on periapical radiographs (PRs) and the Periapical Index (PAI) scoring system. However, existing automated approaches often simplify PAI into binary categories or ignore essential clinical metadata, limiting diagnostic performance and applicability.
Jiyun Lee, Yudam Park, Sunil Kim, Ikbeom Jang   +3 more
wiley   +1 more source

Comparing the Effects of Collaborative and Independent Writing on EFL Learners’ Individual Writing Performance: An Intervention Study

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Collaborative writing has attracted increasing attention in English as a Foreign Language (EFL) instruction due to its potential to enhance learners’ writing competence. However, few studies have examined the comparative effects of collaborative versus independent writing on EFL learners’ individual performance, especially in higher‐order ...
Ting Huang, Chenze Wu, Wenkang Zhang
wiley   +1 more source

Who Bears the Pen? Audit Partner–Manager Report Signatures, Multilevel Accountability and Audit Quality in China

International Journal of Auditing, EarlyView.
ABSTRACT Using data pertaining to China's mandatory two‐signature regime, under which a certified public accountant licensed as an audit manager can serve as an audit report signatory, we examine whether reallocating accountability within the audit engagement team is associated with audit quality.
Yanming Cao, Jengfang Chen, Meiting Lu, Grant Richardson   +3 more
wiley   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source

Toward food-grade production of the Glutamicibacter halophytocola diamine oxidase using Komagataella phaffii

AMB Express
The diamine oxidase from Glutamicibacter halophytocola (DAO-GH) was recombinantly produced in K. phaffii using the constitutive glyceraldehyde-3-phosphate dehydrogenase promoter for methanol-free production. Firstly, K.
Anna Bechtel, Lucas Kettner, Jan Hessenberger, Kenny Vlassakakis, Lutz Fischer   +4 more
doaj   +1 more source

Context‐Dependent Regulation of Epithelial Cell Behaviour by Palatal Connective Tissue Graft‐Derived Fibroblasts via EGF and HB‐EGF Signalling

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate how human palatal fibroblasts (HPFs) from anterior (A) or posterior (P) subepithelial connective tissue grafts (CTGs) regulate oral epithelial cell behaviour, focusing on epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF).
Xiaoqing Song, Cristina Nica, Alexandra Stähli, Anton Sculean, Maria B. Asparuhova   +4 more
wiley   +1 more source