Results 151 to 160 of about 1,789 (171)

Dapivirine Vaginal Ring for HIV-1 Prevention

New England Journal of Medicine, 2017
Jared M, Baeten, Elizabeth R, Brown, Sharon L, Hillier   +2 more
openaire   +6 more sources

Development of Reservoir Vaginal Rings Containing Dapivirine or Hormonal Contraceptive Steroids

AIDS Research and Human Retroviruses, 2014
Background: By extending the use duration of vaginal rings (VRs) the overall production cost per patient per month can be greatly reduced. Matrix-type ring designs produce an initial burst of drug release and concentrations during the burst must be maintained within safe limits. This constrains both the maximum drug load and in turn the use duration of
McCoy, Clare, Boyd, Peter, Fetherston, Susan, Major, Ian, Murphy, Diarmaid, Brimer, Andrew, Holt, Jonathon, Devlin, Brid, Blanda, Wendy, Derrick, Tiffany, Gimour, Chris, Nuttall, Jeremy, Malcolm, Karl   +12 more
openaire   +2 more sources

A Combination Vaginal Ring Releasing Dapivirine and Darunavir

AIDS Research and Human Retroviruses, 2014
Karl Malcolm, Diarmaid Murphy, Delphine Desjardins, Nathalie Dereuddre-Bosquet, Patricia Brochard, Ludivine Perrot, Alain Pruvost, Roger Le Grand, Ole Lagatie, Leen Vanhooren, Maxim Feyaerts, Jens Van Roey   +11 more
openaire   +1 more source

Matrix and core-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel [PDF]

, 2016
A matrix-type silicone elastomer vaginal ring providing 28-day continuous release of dapivirine (DPV) - a lead candidate human immunodeficiency virus type 1 (HIV-1) microbicide compound - has recently demonstrated moderate levels of protection in two Phase III clinical studies.
Boyd, Peter, Fetherston, Susan, Murphy, Diarmaid, McCoy, Clare, Major, Ian, Kumar, Sandeep, Holt, J., Brimer, Andrew, Blanda, Wendy, Devlin, Brid, Malcolm, Robert   +10 more
openaire  

Comparison of dissolution testing methods for the 25 mg dapivirine vaginal ring

2018
Background: Dissolution testing of the 25 mg dapivirine (DPV) vaginal ring has historically relied on a non-compendial shaking incubator method. Typically, individual rings in a sealed glass flask containing a defined volume of release medium are placed in a temperature-controlled shaking incubator.
Malcolm, Robert, McCoy, Clare, Murphy, Diarmaid, Boyd, Peter, Derrick, Tiffany, Spence, Patrick, Devlin, Brid   +6 more
openaire   +1 more source

Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study

Lancet HIV,the, 2021
Nyaradzo M Mgodi, Ashley J Mayo, Brenda Mirembe   +2 more
exaly  

Safety of dapivirine vaginal rings during breastfeeding

The Lancet HIV
Katrina F, Ortblad, Kenneth, Ngure
openaire   +2 more sources

Safety, adherence, and HIV-1 seroconversion among women using the dapivirine vaginal ring (DREAM): an open-label, extension study

Lancet HIV,the, 2021
Allison Carter, Jennifer F Morton, Sylvia Kusemererwa   +2 more
exaly  

Dapivirine vaginal ring reduces HIV infection rates in women

The Pharmaceutical Journal, 2016
openaire   +1 more source

Impact of Dapivirine and Placebo Vaginal Rings on the Microbiota of Adolescent, Lactating, and Postmenopausal Females

Journal of Infectious Diseases, 2021
Beatrice Chen, Lisa Noguchi
exaly