Results 141 to 150 of about 4,072,824 (320)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Dark Future for Dark Matter

Journal of Modern Physics, 2020
The prevailing cosmological constant and cold dark matter (LCDM) cosmic concordance model accounts for the radial expansion of the universe after the Big Bang. The model appears to be authoritative because it is based on the Einstein gravitational field equation.
Eckhardt, D.H., Garrido Pestaña, J.L.
openaire   +5 more sources

Inflaxion dark matter [PDF]

Journal of High Energy Physics, 2019
Abstract A new mechanism for producing axion dark matter is proposed. By invoking low-scale inflation and a kinetic mixing between the axion and the inflaton, it is shown that the axion is driven to a field point slightly displaced from the potential minimum, which can give rise to the observed dark matter abundance.
Kobayashi, T., Ubaldi, L.
openaire   +6 more sources

The Macronova in GRB 050709 and the GRB-macronova connection

Nature Communications, 2016
A macronova is a clear signature that a short gamma-ray burst has been emitted by a compact-binary merger, but evidence of these events is so far scarce.
Zhi-Ping Jin, Kenta Hotokezaka, Xiang Li, Masaomi Tanaka, Paolo D’Avanzo, Yi-Zhong Fan, Stefano Covino, Da-Ming Wei, Tsvi Piran   +8 more
doaj   +1 more source

The evolution of large-scale structure in a universe dominated by cold dark matter

, 1985
The results of numerical simulations of nonlinear gravitational clustering in universes dominated by weakly interacting, 'cold' dark matter are presented.
M. Davis, G. Efstathiou, C. Frenk, S. White   +3 more
semanticscholar   +1 more source

Production of purely gravitational dark matter: the case of fermion and vector boson [PDF]

Journal of High Energy Physics, 2019
We consider the simplest possibility for a model of particle dark matter in which dark matter has only gravitational interaction with the standard model sector.
Yohei Ema, K. Nakayama, Yong Tang
semanticscholar   +1 more source

Dynamical Dark Matter: II. An Explicit Model

, 2012
In a recent paper (arXiv:1106.4546), we introduced "dynamical dark matter," a new framework for dark-matter physics, and outlined its underlying theoretical principles and phenomenological possibilities.
A. G. Doroshkevich, A. G. Doroshkevich, A. G. Doroshkevich, A. G. Doroshkevich, A. G. Doroshkevich, A. H. G. Peter, Brooks Thomas, E. Ma, E. W. Kolb, K. R. Dienes, Keith R. Dienes, S. Dodelson, S. C. Kappadath, Z. G. Berezhiani, Z. G. Berezhiani   +14 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

DARK MATTER AXIONS [PDF]

International Journal of Modern Physics A, 1994
The hypothesis of an 'invisible' axion was made by Misha Shifman and others, approximately thirty years ago. It has turned out to be an unusually fruitful idea, crossing boundaries between particle physics, astrophysics and cosmology. An axion with mass of order 10-5 eV (with large uncertainties) is one of the leading candidates for the dark matter of
Pierre Sikivie, Pierre Sikivie
openaire   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source