Results 161 to 170 of about 1,667,560 (344)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Supernova neutrino induced neutrons in liquid xenon dark matter detectors [PDF]

, 2020
Pijushpani Bhattacharjee, Abhijit Bandyopadhyay, Sovan Chakraborty, Kamales Kar, S. Saha   +4 more
openalex  

Spin-dependent interpretation for possible signals of light dark matter [PDF]

, 2013
Matthew R. Buckley, W. H. Lippincott
openalex   +1 more source

Dark Matter on the Closed Region Connected With Black Hole by Wormhole

, 2021
M. Bousder
openalex   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Extending global fits of 4D Composite Higgs Models with partially composite leptons

Journal of High Energy Physics
We perform the first convergent Bayesian global fits of 4D Composite Higgs Models with partially-composite third generation quarks and leptons based on the minimal SO(5) → SO(4) symmetry breaking pattern.
Ethan Carragher, Kenn Goh, Wei Su, Martin White, Anthony G. Williams   +4 more
doaj   +1 more source

Investigate the interaction between dark matter and dark energy [PDF]

, 2012
Jianbo Lu, Yabo Wu, Yong-Yi Jin, Yan Wang   +3 more
openalex   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Light thermal dark matter beyond p-wave annihilation in minimal Higgs portal model

Journal of High Energy Physics
This study explores a minimal renormalizable dark matter (DM) model, incorporating a sub-GeV Majorana DM and a singlet scalar particle ϕ. Using scalar and pseudo-scalar interactions (couplings c s and c p ), we investigate implications for DM detection ...
Yu-Tong Chen, Shigeki Matsumoto, Tian-Peng Tang, Yue-Lin Sming Tsai, Lei Wu   +4 more
doaj   +1 more source

Gigagauss Magnetic Fields Generated via Theta-Pinching Driven by Multiple Petawatt-Class Lasers

Ultrafast Science
Extremely high axial magnetic fields above the gigagauss level are supposed to exist in neutron stars, which may be a one of the critical parameters for their internal structures and be responsible for the x-ray and gamma-ray emission from these stars ...
Huanyu Song, Zhengming Sheng, Linzheng Wang, Min Chen, Suming Weng, Masakatsu Murakami, Jie Zhang   +6 more
doaj   +1 more source