Results 141 to 150 of about 1,630,167 (297)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Transverse Oscillation of Prominence and Filament Induced by an Extreme-ultraviolet Wave from the Far Side of the Sun

The Astrophysical Journal
In this paper, we report our multi-angle observations of the transverse oscillation of a prominence and a filament induced by an EUV wave originating from the far side of the Sun on 2014 September 1. The prominence oscillation was simultaneously observed
Yanjie Zhang, Qingmin Zhang, De-chao Song, Haisheng Ji   +3 more
doaj   +1 more source

Ultrafast Time-Integrated Diagnosis of Laser-Heated Deuterium Ions in Dense Plasma via Fusion Neutron Spectra

Ultrafast Science
The ultrafast time-integrated diagnosis of ions plays a vital role in high-energy-density physics research. However, it is extremely challenging to measure in experiment.
Jie Feng, Hao Xu, Mingxuan Wei, Mingyang Zhu, Xichen Hu, Bingzhan Shi, Fuyuan Wu, Weijun Zhou, Wenchao Yan, Guoqiang Zhang, Jinguang Wang, Yifei Li, Xin Lu, Liming Chen   +13 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Precise measurement of CP violating τ EDM through e + e − → γ *, ψ(2s) → τ + τ −

Journal of High Energy Physics
A nonzero electric dipole moment of a tauon, d τ , signals CP violation and provides an important probe for new physics. We study methods to measure d τ at low energy e + e − colliders through the processes e + e − → γ *, ψ(2S) → τ + τ − with τ ± decays ...
Xiao-Gang He, Chia-Wei Liu, Jian-Ping Ma, Chang Yang, Zi-Yue Zou   +4 more
doaj   +1 more source

Dark astronomy with dark matter detectors

Journal of Cosmology and Astroparticle Physics
Abstract We present a novel way of probing non-gravitational dark matter interactions: dark astronomy, which leverages the dark radiation emitted by dissipative dark sectors. If the mediator of the dark matter self interactions is a dark photon with a small mass that kinetically mixes with the visible photon, the dark radiation flux ...
Gonzalo Alonso-Álvarez, David Curtin
openaire   +2 more sources

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Dark-Matter–Electron Detectors for Dark-Matter–Nucleon Interactions

Physical Review Letters
In a seminal paper now a decade old, it was shown that dark-matter detectors geared at probing interactions with nucleons could also be used to probe dark-matter interactions with electrons. In this Letter, we show that new detector concepts designed to probe dark-matter–electron interactions at low masses can similarly be used to probe new parameter ...
Sinéad M. Griffin, Guy Daniel Hadas, Yonit Hochberg, Katherine Inzani, Benjamin V. Lehmann   +4 more
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source