Results 41 to 50 of about 12,809 (205)
Pre-Big Bang, space-time structure, asymptotic Universe
EPJ Web of Conferences, 2014 Planck and other recent data in Cosmology and Particle Physics can open the way to controversial analyses concerning the early Universe and its possible ultimate origin.
Gonzalez-Mestres Luis
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A deconstruction of methods to derive one-point lensing statistics
The Open Journal of AstrophysicsGravitational lensing is a crucial tool for exploring cosmic phenomena, providing insights into galaxy clustering, dark matter, and dark energy. Given the substantial computational demands of $N$-body simulations, approximate methods like $\texttt ...
Viviane Alfradique +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Probing the Nonlinear Density Wave Theory of Spiral Galaxies by Baryonic Tully–Fisher Relation
UniverseThe baryonic mass–velocity relation provides an important test of different galaxy dynamics models such as Lambda–cold dark matter (ΛCDM) and alternatives like Modified Newtonian Dynamics (MOND).
Miroslava Vukcevic +2 more
doaj +1 more source
Voices in Bioethics, 2014 Organ transplantation brings up a myriad of bioethical issues, especially with regard to informed consent. In the US, an “opt-in” approach is practiced, in which patients’ organs will not be harvested unless they or their next-of-kin have provided ...
Louisa Howard
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source