Results 21 to 30 of about 12,809 (205)

Pre-Big Bang, fundamental Physics and noncyclic cosmologies

EPJ Web of Conferences, 2014
Detailed analyses of WMAP and Planck data can have significant implications for noncyclic pre-Big Bang approaches incorporating a new fundamental scale beyond the Planck scale and, potentially, new ultimate constituents of matter with unconventional ...
Gonzalez-Mestres L.
doaj   +1 more source

The rising dominance of microbiology: what to expect in the next 15 years?

Microbial Biotechnology, 2022
Summary What microbiology beholds after a decade and a half in the future requires a vision based on the facts and ongoing trends in research and technological advancements.
Roshan Kumar, Utkarsh Sood, Jasvinder Kaur, Shailly Anand, Vipin Gupta, Kishor Sureshbhai Patil, Rup Lal   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Finite-Capacity Spacetime and Entropic Contributions to Cosmological Structure Formation

Physics
We investigatewhether a finite local information capacity of spacetime can account for the gravitational phenomena commonly attributed to cold dark matter.
Florian Neukart, Eike Marx, Valerii Vinokur   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analyzing DGP braneworld model stability through phase space phenomenon

Nuclear Physics B
This study explores the cosmological dynamics of the Dvali-Gabadadze-Porrati (DGP) braneworld model, focusing on its behavior under various forms of nonlinear interaction between dark energy and dark matter.
Abdulmohsen Daham Alruwaili, Abdul Jawad, Ruqia Arif   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Testing Dark Matter with Generative Models for Extragalactic Stellar Streams

The Astrophysical Journal
Upcoming ground- and space-based surveys are poised to illuminate low-surface-brightness tidal features, providing a new observable connection to dark matter physics.
Jacob Nibauer, Sarah Pearson
doaj   +1 more source

Secondary scintillation yield of xenon with sub-percent levels of CO2 additive for rare-event detection

Physics Letters B, 2017
Xe–CO2 mixtures are important alternatives to pure xenon in Time Projection Chambers (TPC) based on secondary scintillation (electroluminescence) signal amplification with applications in the important field of rare event detection such as directional ...
C.A.O. Henriques, E.D.C. Freitas, C.D.R. Azevedo, D. González-Díaz, R.D.P. Mano, M.R. Jorge, L.M.P. Fernandes, C.M.B. Monteiro, J.J. Gómez-Cadenas, V. Álvarez, J.M. Benlloch-Rodríguez, F.I.G.M. Borges, A. Botas, S. Cárcel, J.V. Carríon, S. Cebrían, C.A.N. Conde, J. Díaz, M. Diesburg, R. Esteve, R. Felkai, P. Ferrario, A.L. Ferreira, A. Goldschmidt, R.M. Gutiérrez, J. Hauptman, A.I. Hernandez, J.A. Hernando Morata, V. Herrero, B.J.P. Jones, L. Labarga, A. Laing, P. Lebrun, I. Liubarsky, N. López-March, M. Losada, J. Martín-Albo, G. Martínez-Lema, A. Martínez, A.D. McDonald, F. Monrabal, F.J. Mora, L.M. Moutinho, J. Muñoz Vidal, M. Musti, M. Nebot-Guinot, P. Novella, D.R. Nygren, B. Palmeiro, A. Para, J. Pérez, M. Querol, J. Renner, L. Ripoll, J. Rodríguez, L. Rogers, F.P. Santos, J.M.F. dos Santos, A. Simón, C. Sofka, M. Sorel, T. Stiegler, J.F. Toledo, J. Torrent, Z. Tsamalaidze, J.F.C.A. Veloso, R. Webb, J.T. White, N. Yahlali   +68 more
doaj   +1 more source