Results 101 to 110 of about 38,658 (259)
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, EarlyView.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni +11 morewiley +1 more sourceAn accurate solar axions ray-tracing response of BabyIAXO
Journal of High Energy PhysicsBabyIAXO is the intermediate stage of the International Axion Observatory (IAXO) to be hosted at DESY. Its primary goal is the detection of solar axions following the axion helioscope technique. Axions are converted into photons in a large magnet that is IAXO collaboration, S. Ahyoune, K. Altenmüller, I. Antolín, S. Basso, P. Brun, F. R. Candón, J. F. Castel, S. Cebrián, D. Chouhan, R. Della Ceca, M. Cervera-Cortés, V. Chernov, M. M. Civitani, C. Cogollos, E. Costa, V. Cotroneo, T. Dafní, A. Derbin, K. Desch, M. C. Díaz-Martín, A. Díaz-Morcillo, D. Díez-Ibáñez, C. Diez Pardos, M. Dinter, B. Döbrich, I. Drachnev, A. Dudarev, A. Ezquerro, S. Fabiani, E. Ferrer-Ribas, F. Finelli, I. Fleck, J. Galán, G. Galanti, M. Galaverni, J. A. García, J. M. García-Barceló, L. Gastaldo, M. Giannotti, A. Giganon, C. Goblin, N. Goyal, Y. Gu, L. Hagge, L. Helary, D. Hengstler, D. Heuchel, S. Hoof, R. Iglesias-Marzoa, F. J. Iguaz, C. Iñiguez, I. G. Irastorza, K. Jakovčić, D. Käfer, J. Kaminski, S. Karstensen, M. Law, A. Lindner, M. Loidl, C. Loiseau, G. López-Alegre, A. Lozano-Guerrero, B. Lubsandorzhiev, G. Luzón, I. Manthos, C. Margalejo, A. Marín-Franch, J. Marqués, F. Marutzky, C. Menneglier, M. Mentink, S. Mertens, J. Miralda-Escudé, H. Mirallas, F. Muleri, V. Muratova, J. R. Navarro-Madrid, X. F. Navick, K. Nikolopoulos, A. Notari, A. Nozik, L. Obis, A. Ortiz-de-Solórzano, T. O’Shea, J. von Oy, G. Pareschi, T. Papaevangelou, G. Pareschi, K. Perez, O. Pérez, E. Picatoste, M. J. Pivovaroff, J. Porrón, M. J. Puyuelo, A. Quintana, J. Redondo, D. Reuther, A. Ringwald, M. Rodrigues, A. Rubini, S. Rueda-Teruel, F. Rueda-Teruel, E. Ruiz-Chóliz, J. Ruz, J. Schaffran, T. Schiffer, S. Schmidt, U. Schneekloth, L. Schönfeld, M. Schott, L. Segui, U. R. Singh, P. Soffitta, D. Spiga, M. Stern, O. Straniero, F. Tavecchio, E. Unzhakov, N. A. Ushakov, G. Vecchi, J. K. Vogel, D. M. Voronin, R. Ward, A. Weltman, C. Wiesinger, R. Wolf, A. Yanes-Díaz, Y. Yu +128 moredoaj +1 more sourceElectroluminescence TPCs at the thermal diffusion limit
Journal of High Energy Physics, 2019 The NEXT experiment aims at searching for the hypothetical neutrinoless double-beta decay from the 136Xe isotope using a high-purity xenon TPC. Efficient discrimination of the events through pattern recognition of the topology of primary ionisation ...The NEXT collaboration, C. A. O. Henriques, C. M. B. Monteiro, D. González-Díaz, C. D. R Azevedo, E. D. C. Freitas, R. D. P. Mano, M. R. Jorge, A. F. M. Fernandes, J. J. Gómez-Cadenas, L. M. P. Fernandes, C. Adams, V. Álvarez, L. Arazi, K. Bailey, F. Ballester, J. M. Benlloch-Rodríguez, F. I. G. M. Borges, A. Botas, S. Cárcel, J. V. Carrión, S. Cebrián, C. A. N. Conde, J. Díaz, M. Diesburg, J. Escada, R. Esteve, R. Felkai, P. Ferrario, A. L. Ferreira, J. Generowicz, A. Goldschmidt, R. Guenette, R. M. Gutiérrez, K. Hafidi, J. Hauptman, A. I. Hernandez, J. A. Hernando Morata, V. Herrero, S. Johnston, B. J. P. Jones, M. Kekic, L. Labarga, A. Laing, P. Lebrun, N. López-March, M. Losada, J. Martín-Albo, A. Martínez, G. Martínez-Lema, A. McDonald, F. Monrabal, F. J. Mora, J. Muñoz Vidal, M. Musti, M. Nebot-Guinot, P. Novella, D. R. Nygren, B. Palmeiro, A. Para, J. Pérez, F. Psihas, M. Querol, J. Renner, J. Repond, S. Riordan, L. Ripoll, J. Rodríguez, L. Rogers, C. Romo-Luque, F. P. Santos, J. M. F. dos Santos, A. Simón, C. Sofka, M. Sorel, T. Stiegler, J. F. Toledo, J. Torrent, J. F. C. A. Veloso, R. Webb, J. T. White, N. Yahlali +81 moredoaj +1 more sourceOvarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development
Advanced Science, EarlyView.The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang +12 morewiley +1 more sourceNeuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
Advanced Science, EarlyView.ABSTRACT
The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer +17 morewiley +1 more sourceDe Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li +23 morewiley +1 more sourceHepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK
Advanced Science, EarlyView.Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT
Liver is a central organ for lipid Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang +14 morewiley +1 more sourcePhenomenological modeling of the 163Ho calorimetric electron capture spectrum from the HOLMES experiment
Journal of High Energy PhysicsWe present a comprehensive phenomenological analysis of the calorimetric electron capture (EC) decay spectrum of 163Ho as measured by the HOLMES experiment.The HOLMES collaboration, F. Ahrens, B. K. Alpert, D. T. Becker, D. A. Bennett, E. Bogoni, M. Borghesi, P. Campana, R. Carobene, A. Cattaneo, A. Cian, H. A. Corti, N. Crescini, M. De Gerone, W. B. Doriese, M. Faverzani, L. Ferrari Barusso, E. Ferri, J. Fowler, G. Gallucci, S. Gamba, J. D. Gard, H. Garrone, F. Gatti, A. Giachero, M. Gobbo, A. Irace, U. Köster, D. Labranca, M. Lusignoli, F. Malnati, F. Mantegazzini, B. Margesin, J. A. B. Mates, E. Maugeri, R. Mezzena, E. Monticone, R. Moretti, A. Nucciotti, G. C. O’Neil, L. Origo, G. Pessina, S. Ragazzi, M. Rajteri, C. D. Reintsema, D. R. Schmidt, D. S. Swetz, Z. Talip, J. N. Ullom, L. R. Vale +49 moredoaj +1 more sourceTargeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer
Advanced Science, EarlyView.An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT
The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai +11 morewiley +1 more source
