Results 111 to 120 of about 2,177 (259)

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Phenomenological modeling of the 163Ho calorimetric electron capture spectrum from the HOLMES experiment

Journal of High Energy Physics
We present a comprehensive phenomenological analysis of the calorimetric electron capture (EC) decay spectrum of 163Ho as measured by the HOLMES experiment.
The HOLMES collaboration, F. Ahrens, B. K. Alpert, D. T. Becker, D. A. Bennett, E. Bogoni, M. Borghesi, P. Campana, R. Carobene, A. Cattaneo, A. Cian, H. A. Corti, N. Crescini, M. De Gerone, W. B. Doriese, M. Faverzani, L. Ferrari Barusso, E. Ferri, J. Fowler, G. Gallucci, S. Gamba, J. D. Gard, H. Garrone, F. Gatti, A. Giachero, M. Gobbo, A. Irace, U. Köster, D. Labranca, M. Lusignoli, F. Malnati, F. Mantegazzini, B. Margesin, J. A. B. Mates, E. Maugeri, R. Mezzena, E. Monticone, R. Moretti, A. Nucciotti, G. C. O’Neil, L. Origo, G. Pessina, S. Ragazzi, M. Rajteri, C. D. Reintsema, D. R. Schmidt, D. S. Swetz, Z. Talip, J. N. Ullom, L. R. Vale   +49 more
doaj   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Searching for millicharged particles with 1 kg of Skipper-CCDs using the NuMI beam at Fermilab

Journal of High Energy Physics
Oscura is a planned light-dark matter search experiment using Skipper-CCDs with a total active mass of 10 kg. As part of the detector development, the collaboration plans to build the Oscura Integration Test (OIT), an engineering test with 10% of the ...
Santiago Perez, Dario Rodrigues, Juan Estrada, Roni Harnik, Zhen Liu, Brenda A. Cervantes-Vergara, Juan Carlos D’Olivo, Ryan D. Plestid, Javier Tiffenberg, Tien-Tien Yu, Alexis Aguilar-Arevalo, Fabricio Alcalde-Bessia, Nicolás Avalos, Oscar Baez, Daniel Baxter, Xavier Bertou, Carla Bonifazi, Ana Botti, Gustavo Cancelo, Nuria Castelló-Mor, Alvaro E. Chavarria, Claudio R. Chavez, Fernando Chierchie, Juan Manuel De Egea, Cyrus Dreyer, Alex Drlica-Wagner, Rouven Essig, Ezequiel Estrada, Erez Etzion, Paul Grylls, Guillermo Fernandez-Moroni, Marivi Fernández-Serra, Santiago Ferreyra, Stephen Holland, Agustín Lantero Barreda, Andrew Lathrop, Ian Lawson, Ben Loer, Steffon Luoma, Edgar Marrufo Villalpando, Mauricio Martinez Montero, Kellie McGuire, Jorge Molina, Sravan Munagavalasa, Danielle Norcini, Alexander Piers, Paolo Privitera, Nathan Saffold, Richard Saldanha, Aman Singal, Radomir Smida, Miguel Sofo-Haro, Diego Stalder, Leandro Stefanazzi, Michelangelo Traina, Yu-Dai Tsai, Sho Uemura, Pedro Ventura, Rocío Vilar Cortabitarte, Rachana Yajur   +59 more
doaj   +1 more source

First evidence for neutrinoless doubly beta decay and world status of double beta experiments

, 2005
The occurrence of the neutrinoless decay 0n-bb mode has fundamental consequences: first total lepton number is not conserved, and second, the neutrino is a Majorana particle.
Klapdor-Kleingrothaus, H., Klapdor-Kleingrothaus, Hans Volker   +1 more
core  

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Measurement of two-neutrino double electron capture half-life of 124Xe with PandaX-4T

Journal of High Energy Physics
Detailed studies of two-neutrino double electron capture (2νDEC) is a crucial step towards searching for the neutrinoless mode to explore the Majorana nature of neutrinos.
The PandaX-4T collaboration, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Zhaokan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Zhixing Gao, Lisheng Geng, Karl Giboni, Xunan Guo, Xuyuan Guo, Zichao Guo, Chencheng Han, Ke Han, Changda He, Jinrong He, Di Huang, Houqi Huang, Junting Huang, Ruquan Hou, Yu Hou, Xiangdong Ji, Xiangpan Ji, Yonglin Ju, Chenxiang Li, Jiafu Li, Mingchuan Li, Shuaijie Li, Tao Li, Zhiyuan Li, Qing Lin, Jianglai Liu, Congcong Lu, Xiaoying Lu, Lingyin Luo, Yunyang Luo, Wenbo Ma, Yugang Ma, Yajun Mao, Yue Meng, Xuyang Ning, Binyu Pang, Ningchun Qi, Zhicheng Qian, Xiangxiang Ren, Dong Shan, Xiaofeng Shang, Xiyuan Shao, Guofang Shen, Manbin Shen, Wenliang Sun, Yi Tao, Anqing Wang, Guanbo Wang, Hao Wang, Jiamin Wang, Lei Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Xu Wang, Zhou Wang, Yuehuan Wei, Weihao Wu, Yuan Wu, Mengjiao Xiao, Xiang Xiao, Kaizhi Xiong, Yifan Xu, Shunyu Yao, Binbin Yan, Xiyu Yan, Yong Yang, Peihua Ye, Chunxu Yu, Ying Yuan, Zhe Yuan, Youhui Yun, Xinning Zeng, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Wei Zhang, Yang Zhang, Yingxin Zhang, Yuanyuan Zhang, Li Zhao, Jifang Zhou, Jiaxu Zhou, Jiayi Zhou, Ning Zhou, Xiaopeng Zhou, Yubo Zhou, Zhizhen Zhou   +101 more
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source