Results 111 to 120 of about 38,658 (259)

Searching for millicharged particles with 1 kg of Skipper-CCDs using the NuMI beam at Fermilab

Journal of High Energy Physics
Oscura is a planned light-dark matter search experiment using Skipper-CCDs with a total active mass of 10 kg. As part of the detector development, the collaboration plans to build the Oscura Integration Test (OIT), an engineering test with 10% of the ...
Santiago Perez, Dario Rodrigues, Juan Estrada, Roni Harnik, Zhen Liu, Brenda A. Cervantes-Vergara, Juan Carlos D’Olivo, Ryan D. Plestid, Javier Tiffenberg, Tien-Tien Yu, Alexis Aguilar-Arevalo, Fabricio Alcalde-Bessia, Nicolás Avalos, Oscar Baez, Daniel Baxter, Xavier Bertou, Carla Bonifazi, Ana Botti, Gustavo Cancelo, Nuria Castelló-Mor, Alvaro E. Chavarria, Claudio R. Chavez, Fernando Chierchie, Juan Manuel De Egea, Cyrus Dreyer, Alex Drlica-Wagner, Rouven Essig, Ezequiel Estrada, Erez Etzion, Paul Grylls, Guillermo Fernandez-Moroni, Marivi Fernández-Serra, Santiago Ferreyra, Stephen Holland, Agustín Lantero Barreda, Andrew Lathrop, Ian Lawson, Ben Loer, Steffon Luoma, Edgar Marrufo Villalpando, Mauricio Martinez Montero, Kellie McGuire, Jorge Molina, Sravan Munagavalasa, Danielle Norcini, Alexander Piers, Paolo Privitera, Nathan Saffold, Richard Saldanha, Aman Singal, Radomir Smida, Miguel Sofo-Haro, Diego Stalder, Leandro Stefanazzi, Michelangelo Traina, Yu-Dai Tsai, Sho Uemura, Pedro Ventura, Rocío Vilar Cortabitarte, Rachana Yajur   +59 more
doaj   +1 more source

Development and properties of cadmium and lead tungstate low-background scintillators for double beta decay experiments [PDF]

Ядерна фізика та енергетика, 2014
Methods of deep purification of natural and isotopically enriched cadmium (Cd, 106Cd, 116Cd), as well as of archaeological lead (archPb), to produce cadmium and lead tungstate crystal scintillators have been developed. The basic stages of development and
G. P. Kovtun, R. S. Boiko, F. A. Danevich, B. N. Kropivyansky, V. M. Mokina, T. S. Potina, D. A. Solopikhin, I. A. Tupitsyna, A. P. Shcherban, V. N. Shlegel   +9 more
doaj  

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Measurement of two-neutrino double electron capture half-life of 124Xe with PandaX-4T

Journal of High Energy Physics
Detailed studies of two-neutrino double electron capture (2νDEC) is a crucial step towards searching for the neutrinoless mode to explore the Majorana nature of neutrinos.
The PandaX-4T collaboration, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Zhaokan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Zhixing Gao, Lisheng Geng, Karl Giboni, Xunan Guo, Xuyuan Guo, Zichao Guo, Chencheng Han, Ke Han, Changda He, Jinrong He, Di Huang, Houqi Huang, Junting Huang, Ruquan Hou, Yu Hou, Xiangdong Ji, Xiangpan Ji, Yonglin Ju, Chenxiang Li, Jiafu Li, Mingchuan Li, Shuaijie Li, Tao Li, Zhiyuan Li, Qing Lin, Jianglai Liu, Congcong Lu, Xiaoying Lu, Lingyin Luo, Yunyang Luo, Wenbo Ma, Yugang Ma, Yajun Mao, Yue Meng, Xuyang Ning, Binyu Pang, Ningchun Qi, Zhicheng Qian, Xiangxiang Ren, Dong Shan, Xiaofeng Shang, Xiyuan Shao, Guofang Shen, Manbin Shen, Wenliang Sun, Yi Tao, Anqing Wang, Guanbo Wang, Hao Wang, Jiamin Wang, Lei Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Xu Wang, Zhou Wang, Yuehuan Wei, Weihao Wu, Yuan Wu, Mengjiao Xiao, Xiang Xiao, Kaizhi Xiong, Yifan Xu, Shunyu Yao, Binbin Yan, Xiyu Yan, Yong Yang, Peihua Ye, Chunxu Yu, Ying Yuan, Zhe Yuan, Youhui Yun, Xinning Zeng, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Wei Zhang, Yang Zhang, Yingxin Zhang, Yuanyuan Zhang, Li Zhao, Jifang Zhou, Jiaxu Zhou, Jiayi Zhou, Ning Zhou, Xiaopeng Zhou, Yubo Zhou, Zhizhen Zhou   +101 more
doaj   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Lewis Pair‐Engineered CuMnOx as Cold‐Adapted Multinanozyme for Cooperative Hydrolytic and Oxidative Degradation of Raw Corn Stalk

Advanced Science, EarlyView.
A Lewis pair site design strategy was established to construct Cu‐doped Mn‐based amorphous nanozymes, where Mn and oxygen vacancies generate cooperative acid‐base pairs. The resulting multinanozyme integrates glycosidase‐, oxidase‐, and cold‐adapted enzyme‐mimicking activities, enabling cooperative depolymerization of cellulose and hemicellulose ...
Huile Liu, Ziyi Di, Qing Tian, Yue Zhou, Rong Yang, Zhiyi Bai, Haoyu Wang, Yao Chen, Lianbing Zhang   +8 more
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source