Results 81 to 90 of about 1,681 (230)
Development and properties of cadmium and lead tungstate low-background scintillators for double beta decay experiments [PDF]
Ядерна фізика та енергетика, 2014 Methods of deep purification of natural and isotopically enriched cadmium (Cd, 106Cd, 116Cd), as well as of archaeological lead (archPb), to produce cadmium and lead tungstate crystal scintillators have been developed. The basic stages of development and G. P. Kovtun, R. S. Boiko, F. A. Danevich, B. N. Kropivyansky, V. M. Mokina, T. S. Potina, D. A. Solopikhin, I. A. Tupitsyna, A. P. Shcherban, V. N. Shlegel +9 moredoaj Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU
Advanced Science, EarlyView.Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu +22 morewiley +1 more sourceMeasurement of two-neutrino double electron capture half-life of 124Xe with PandaX-4T
Journal of High Energy PhysicsDetailed studies of two-neutrino double electron capture (2νDEC) is a crucial step towards searching for the neutrinoless mode to explore the Majorana nature of neutrinos.The PandaX-4T collaboration, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Zhaokan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Zhixing Gao, Lisheng Geng, Karl Giboni, Xunan Guo, Xuyuan Guo, Zichao Guo, Chencheng Han, Ke Han, Changda He, Jinrong He, Di Huang, Houqi Huang, Junting Huang, Ruquan Hou, Yu Hou, Xiangdong Ji, Xiangpan Ji, Yonglin Ju, Chenxiang Li, Jiafu Li, Mingchuan Li, Shuaijie Li, Tao Li, Zhiyuan Li, Qing Lin, Jianglai Liu, Congcong Lu, Xiaoying Lu, Lingyin Luo, Yunyang Luo, Wenbo Ma, Yugang Ma, Yajun Mao, Yue Meng, Xuyang Ning, Binyu Pang, Ningchun Qi, Zhicheng Qian, Xiangxiang Ren, Dong Shan, Xiaofeng Shang, Xiyuan Shao, Guofang Shen, Manbin Shen, Wenliang Sun, Yi Tao, Anqing Wang, Guanbo Wang, Hao Wang, Jiamin Wang, Lei Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Xu Wang, Zhou Wang, Yuehuan Wei, Weihao Wu, Yuan Wu, Mengjiao Xiao, Xiang Xiao, Kaizhi Xiong, Yifan Xu, Shunyu Yao, Binbin Yan, Xiyu Yan, Yong Yang, Peihua Ye, Chunxu Yu, Ying Yuan, Zhe Yuan, Youhui Yun, Xinning Zeng, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Wei Zhang, Yang Zhang, Yingxin Zhang, Yuanyuan Zhang, Li Zhao, Jifang Zhou, Jiaxu Zhou, Jiayi Zhou, Ning Zhou, Xiaopeng Zhou, Yubo Zhou, Zhizhen Zhou +101 moredoaj +1 more sourceSingle‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma
Advanced Science, EarlyView.Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang +12 morewiley +1 more sourceA Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity
Advanced Science, EarlyView.In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi +19 morewiley +1 more sourceAn Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm
Advanced Science, EarlyView.An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang +7 morewiley +1 more sourceIL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma
Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu +16 morewiley +1 more sourceSearch for solar axions produced through the axion-electron coupling g ae using a new GridPix detector at CAST
Journal of High Energy PhysicsWe present a search for solar axions produced through the axion-electron coupling (g ae ) using data from a novel 7-GridPix detector installed at the CERN Axion Solar Telescope (CAST).The CAST collaboration, K. Altenmüller, V. Anastassopoulos, S. Arguedas-Cuendis, S. Aune, J. Baier, K. Barth, H. Bräuninger, G. Cantatore, F. Caspers, J. F. Castel, S. A. Çetin, F. Christensen, C. Cogollos, T. Dafni, M. Davenport, T. A. Decker, K. Desch, D. Díez-Ibáñez, B. Döbrich, E. Ferrer-Ribas, H. Fischer, W. Funk, J. Galán, J. A. García, A. Gardikiotis, I. Giomataris, J. Golm, C. H. Hailey, M. D. Hasinoff, D. H. H. Hoffmann, I. G. Irastorza, J. Jacoby, A. C. Jakobsen, K. Jakovčić, J. Kaminski, M. Karuza, S. Kostoglou, C. Krieger, B. Lakić, J. M. Laurent, G. Luzón, C. Malbrunot, C. Margalejo, M. Maroudas, L. Miceli, H. Mirallas, P. Navarro, L. Obis, A. Özbey, K. Özbozduman, T. Papaevangelou, O. Pérez, M. J. Pivovaroff, M. Rosu, E. Ruiz-Chóliz, J. Ruz, T. Schiffer, S. Schmidt, M. Schumann, Y. K. Semertzidis, S. K. Solanki, L. Stewart, T. Vafeiadis, J. K. Vogel, K. Zioutas +65 moredoaj +1 more sourceEngineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena +11 morewiley +1 more source
