Results 91 to 100 of about 22,137 (292)

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang, Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen   +13 more
wiley   +1 more source

Probing left-handed heavy neutral leptons in the Vector Scotogenic Model

Journal of High Energy Physics
In this work, we consider an extension to the Standard Model composed by a Massive Vector Doublet under SU(2) L and a Left-handed Heavy Neutral Lepton.
C. Paulo Areyuna, Jilberto Zamora-Saa, Alfonso R. Zerwekh   +2 more
doaj   +1 more source

Connection ofg−2μ, electroweak, dark matter, and collider constraints on 331 models [PDF]

, 2014
Chris Kelso, H. N. Long, R. Martı́nez, Farinaldo S. Queiroz   +3 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source

Dark sector glueballs at the LHC

Journal of High Energy Physics
We study confining dark sectors where the lightest hadrons are glueballs. Such models can provide viable dark matter candidates and appear in some neutral naturalness scenarios.
Austin Batz, Timothy Cohen, David Curtin, Caleb Gemmell, Graham D. Kribs   +4 more
doaj   +1 more source

Two component dark matter with inert Higgs doublet: neutrino mass, high scale validity and collider searches [PDF]

, 2020
Subhaditya Bhattacharya, Purusottam Ghosh, Abhijit Kumar Saha, Arunansu Sil   +3 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Probing the MSSM explanation of the muon g-2 anomaly in dark matter experiments and at a 100 TeV pp collider [PDF]

, 2017
Archil Kobakhidze, Matthew Talia, Lei Wu
openalex   +1 more source

ILC Cosmology

, 2005
Recent breakthroughs in cosmology pose questions that require particle physics answers. I review the problems of dark matter, baryogenesis, and dark energy and discuss how particle colliders, particularly the International Linear Collider, may advance ...
Feng, Jonathan L.
core