Results 91 to 100 of about 22,237 (331)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Updated Post-WMAP Benchmarks for Supersymmetry

, 2003
We update a previously-proposed set of supersymmetric benchmark scenarios, taking into account the precise constraints on the cold dark matter density obtained by combining WMAP and other cosmological data, as well as the LEP and b -> s gamma constraints.
148, 22, 25, A. De Roeck, Allanach, Baer, Baer, Belanger, Carena, Collaboration], Collaboration], Drees, Drees, Ellis, Ellis, Ellis, Ellis, F. Gianotti, Feng, Heinemeyer, Hinchliffe, J. Ellis, K. A. Olive, Kane, L. Pape, Lahanas, M. Battaglia, Maiani, Pierce, See   +29 more
core   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Production of dark photons through higher electromagnetic moments at LDMX: simulations and model discrimination

Journal of High Energy Physics
We extend the projected sensitivity of LDMX for sub-GeV dark matter (DM) to the case of dark photons produced through higher order electromagnetic moments. These moments arise from loop diagrams involving portal matter fields, along with the gauge fields
Riccardo Catena, Taylor R. Gray, Thomas Jerkvall   +2 more
doaj   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Complex dark photon dark matter EFT

Journal of High Energy Physics
We construct an effective field theory for complex Stueckelberg dark photon dark matter. Such an effective construction can be realized by writing down a complete set of operators up to dimension six built with the complex dark photon and Standard Model ...
Enrico Bertuzzo, Tommaso Sassi, Andrea Tesi   +2 more
doaj   +1 more source

Distinguishing Dynamical Dark Matter at the LHC

, 2012
Dynamical dark matter (DDM) is a new framework for dark-matter physics in which the dark sector comprises an ensemble of individual component fields which collectively conspire to act in ways that transcend those normally associated with dark matter ...
Dienes, Keith R., Su, Shufang, Thomas, Brooks   +2 more
core   +2 more sources

Vector Boson Fusion topology and simplified models for dark matter searches at colliders [PDF]

, 2021
Santiago Duque-Escobar, Daniel Ocampo-Henao, J. D. Ruiz Alvarez   +2 more
openalex   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

TeV-Scale Seesaw with Loop-Induced Dirac Mass Term and Dark Matter from U(1)_{B-L} Gauge Symmetry Breaking

, 2012
We show a TeV-scale seesaw model where Majorana neutrino masses, the dark matter mass, and stability of the dark matter can be all originated from the U(1)_{B-L} gauge symmetry. Dirac mass terms for neutrinos are forbidden at the tree level by U(1)_{B-L},
Kanemura, Shinya, Nabeshima, Takehiro, Sugiyama, Hiroaki   +2 more
core   +1 more source