Results 41 to 50 of about 8,132 (267)
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
Compact Binary Merger Rate in Dark-matter Spikes
The Astrophysical Journal, 2023 Today, the existence of supermassive black holes (SMBHs) in the center of galactic halos is almost confirmed. An extremely dense region referred to as dark-matter spike is expected to form around central SMBHs as they grow and evolve adiabatically.
Saeed Fakhry +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
European Physical Journal C: Particles and FieldsIn this work, we present the exact solution of a static, spherically symmetric black hole embedded in a Dehnen $$\left( 1,4,\frac{1}{2}\right) $$ 1 , 4 , 1 2 dark matter halo. We explore both its optical and thermodynamic properties.
David Senjaya
doaj +1 more source
On the Mass Dependence of the Inner Slopes of Dark Matter Density Profiles
Open Astronomy, 2014 We study through a semi-analytic model how the inner slopes of relaxed ΛCDM dark matter halos with and without baryons depend on the halo mass. We find that the inner logarithmic density slope, α ≡ d log ρ/d log r, of dark matter halos with baryons has a
Del Popolo A.
doaj +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
The Astrophysical JournalLow-surface-brightness galaxies are excellent laboratories, where stars and baryonic matter act as tracers of the gravitational potential of the dark matter halo.
A. Aceña +4 more
doaj +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source