Results 71 to 80 of about 117,029 (345)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Particle motion and QPOs around Euler-Heisenberg black hole immersed in cold dark matter halo
Nuclear Physics BWe explore the motion of particles in the vicinity of an Euler-Heisenberg black hole immersed in a cold dark matter halo, focusing on how the black hole parameters influence particle dynamics. This black hole solution is characterized by five parameters,
G. Mustafa +6 more
doaj +1 more source
Halo-Independent Direct Detection Analyses Without Mass Assumptions
, 2015 Results from direct detection experiments are typically interpreted by employing an assumption about the dark matter velocity distribution, with results presented in the $m_\chi-\sigma_n$ plane.
Anderson, Adam J. +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The impact of baryonic discs on the shapes and profiles of self-interacting dark matter halos
, 2018 We employ isolated N-body simulations to study the response of self-interacting dark matter (SIDM) halos in the presence of the baryonic potentials. Dark matter self-interactions lead to kinematic thermalization in the inner halo, resulting in a tight ...
Creasey, Peter +5 more
core +1 more source
The Blackhole-Dark Matter Halo Connection [PDF]
, 2015 We explore the connection between the central supermassive blackholes (SMBH) in galaxies and the dark matter halo through the relation between the masses of the SMBHs and the maximum circular velocities of the host galaxies, as well as the relationship ...
Akl, Maya Abi +3 more
core +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Dissipative dark matter halos: The steady state solution
, 2018 Dissipative dark matter, where dark matter particle properties closely resemble familiar baryonic matter, is considered. Mirror dark matter, which arises from an isomorphic hidden sector, is a specific and theoretically constrained scenario.
Foot, R.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Using frequency maps to explore the distribution function of the Milky Way stellar halo
EPJ Web of Conferences, 2012 Resolved surveys of the Milky Way's stellar halo can obtain all 6 phase space coordinates of tens of thousands of individual stars, making it possible to compute their 3-dimensional orbits.
Valluri M.
doaj +1 more source