Results 51 to 60 of about 10,983 (287)
Biomolecules, 2020 Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult.
Yonghyo Kim +13 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
CR-DARTS: Channel Redistribution-Based Differentiable Architecture Search
IEEE AccessDifferentiable Architecture Search (DARTS) has shown promising results in automating the design of deep learning models. However, its search process is computationally expensive because it evaluates all candidate operations simultaneously, often leading ...
Ali Hassan +3 more
doaj +1 more source
open Delft Advanced Research Terra Simulator (open-DARTS)
Subsurface reservoirs are used for various applications that are part of the energy transition toward zero-carbon energy sources. They can serve as a direct source of energy (geothermal production), cyclic energy storage required by renewable energy ...
Orozco, Luisa +6 more
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
IET Computer Vision, 2022 Although YOLOv4 has a high detection accuracy, its backbone network CSPDarknet53 requires a large number of parameters, which reduces the inference speed of the detection network to some extent.
Zhiqiang Xing, Xi Chen, Fengqian Pang
doaj +1 more source
The Journal of Thoracic and Cardiovascular Surgery, 1986 We report on two young patients with unusual airway foreign bodies: blowgun darts. These homemade darts are constructed with yarn, thread, and a common pin. Because only the pin is radiopaque, and because the child may be reluctant to disclose the nature of the foreign body, the bronchoscopist may encounter unexpected difficulty in extracting the dart.
T J, Vander Salm, N, Ellis
openaire +2 more sources