Results 81 to 90 of about 10,983 (287)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

A retractable barb needle for drug darts

Koedoe: African Protected Area Conservation and Science, 1973
The mechanism and action of a new retractable barbneedle for drug darts are described. This dart needle is particularly successful in obviating unnecessary flight reactions andtrauma in darted animals, and facilitates the complete injection of the drug ...
G.L. van Rooyen, P.J. de Beer
doaj   +1 more source

Statistical modelling in professional darts [PDF]

openLa tesi si concentra sull'analisi delle prestazioni dei giocatori di freccette mediante l'applicazione del modello Bradley-Terry. Inizialmente, sono state identificate e create le variabili di interesse attraverso un dataset ottenuto da esperti del ...
GASTALDELLO, MATTEO
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

DART

, 2018
Affix-based search is a fundamental functionality for storage systems. It allows users to find desired datasets, where attributes of a dataset match an affix. While building inverted index to facilitate efficient affix-based keyword search is a common practice for standalone databases and for desktop file systems, building local indexes or adopting ...
Zhang, Wei, Tang, Houjun, Byna, Suren, Chen, Yong   +3 more
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

DARTS: an open-source Python pipeline for Ca2+ microdomain analysis in live cell imaging data

Frontiers in Immunology
Ca2+ microdomains play a key role in intracellular signaling processes. For instance, they mediate the activation of T cells and, thus, the initial adaptive immune system.
Lena-Marie Woelk, Lena-Marie Woelk, Lena-Marie Woelk, Dejan Kovacevic, Hümeyra Husseini, Hümeyra Husseini, Hümeyra Husseini, Fritz Förster, Fritz Förster, Fritz Förster, Fynn Gerlach, Franziska Möckl, Marcus Altfeld, Andreas H. Guse, Björn-Philipp Diercks, René Werner, René Werner, René Werner   +17 more
doaj   +1 more source

AFTER DART: THE DIDYMOS SYSTEM IN THE AFTERMATH OF THE DART EVENT [PDF]

, 2023
ear-Earth objects (NEOs), due to their proximity to our planet, represent one of the most accessible bodies in the whole Solar System. Their investigation, other than providing vital information to planetary formation and water delivery, is compelling due to the hazard these bodies pose to human civilization. The DART/LICIACube mission: To this purpose,
S Ieva, E Mazzotta Epifani, V Petropoulou, J D P Deshapriya, P H Hasselmann, D Perna, M Dall'Ora, G Poggiali, JR Brucato, M Pajola, A Lucchetti, S Ivanovski, A Rossi, P Palumbo, V Della Corte, A Zinzi, C Thomas, J de Leon, AS Rivkin, E Dotto, M Amoroso, I Bertini, A Capannolo, S Caporali, M Ceresoli, G Cremonese, I Gai, L Gomez Casajus, E Gramigna, G Impresario, R Lasagni Manghi, M Lavagna, M Lombardo, D Modenini, S Pirrotta, P Tortora, F Tusberti, M Zannoni, G Zanotti   +38 more
openaire