Results 201 to 210 of about 46,296 (251)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Ultrasensitive serum interferon alpha equals interferon signatures as a marker of lupus disease activity. [PDF]

iScience
Rodríguez-García M, Gómez-Bernal F, Quevedo-Abeledo JC, Tejera-Segura B, García-Barrera E, Villar LM, Ocejo-Vinyals JG, Mota-Pérez N, Largo R, González-Gay MÁ, Ferraz-Amaro I.   +10 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Induction of Cure in Early Arthritis (I CEA): results of a randomised clinical trial to compare three treatment strategies in recent onset undifferentiated arthritis. [PDF]

RMD Open
Nevins IS, van der Pol JA, Van Ouwerkerk L, Helmich GS, Bos R, Van Der Kooij SM, Vonkeman HE, Bijsterbosch J, de Jong PHP, Güler-Yüksel M, Böhringer S, Huizinga TWJ, van Gaalen FA, Bergstra SA.   +13 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Investigating the Link Between Specific Signaling Molecules (CCL5, CCR5, CXCR4, BMPR2) and Cardiac Health Indicators in Rheumatoid Arthritis Individuals: A Cross-Sectional Study. [PDF]

Health Sci Rep
Hassan NH, Khoobbakht F, Shamsi A, Roghani SA, Assar S, Pournazari M, Taghadosi M.   +6 more
europepmc   +1 more source

Dual-domain adversarial learning and feature constraint for unsupervised anomaly detection in chest X-rays. [PDF]

Front Med (Lausanne)
Liang N, Tong Y, Zhang X, Wu X, Wang C, Wang P.   +5 more
europepmc   +1 more source

Impact of social isolation on older outpatients during the COVID-19 pandemic. [PDF]

Einstein (Sao Paulo)
Zilotti LT, Romanos AE, Takahashi MKN, Busse AL, Jacob Filho W.   +4 more
europepmc   +1 more source