Results 71 to 80 of about 6,328,289 (290)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Episode 77: Empathy and Animal Ethics with Elisa Aaltola

, 2018
In this episode of Knowing Animals we speak to Elisa Aaltola from the University of East Finland. We discuss her latest book ‘Varieties of Empathy: Moral Psychology and Animal Ethics’ which is published by Rowman ...
O'Sullivan, Siobhan, Aaltola, Elisa
core   +1 more source

Application of remote sensing techniques for the identification of biotic stress in plum trees caused by the Plum pox virus

Folia Horticulturae, 2015
Two hyperspectral remote sensing techniques, spectral reflectance and chlorophyll fluorescence, were used for the identification of biotic stress (sharka disease) in plum trees at an early stage without visible symptoms on the leaves.
Krezhova Dora, Stoev Antoniy, Petrov Nikolay, Maneva Svetla   +3 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The Occurrence of the Viruses in Tulip Crops in Poland

Journal of Horticultural Research, 2013
The viruses infecting tulips have a big influence on the yield and the quality of bulbs and forced flowers. Commercial bulb production is based on clonal propagation, which leads to the accumulation of viruses.
Sochacki Dariusz
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Correlations between symptoms and DAS - Elisa values in two sources of resistance against tomato spotted wilt virus [PDF]

Brazilian Journal of Microbiology, 2000
The commercial tomato, Lycopersicon esculentum, cultivars Ângela Gigante I-5100 and Santa Clara (tospovirus susceptible), the Stevens cultivar, lines and experimental hybrids (tospovirus resistant), were used: a) to evaluate two sources of resistance to tospoviruses in tomato (one from L.
Resende, Luciane V., Maluf, Wilson R., Figueira, Antônia dos R., Resende, Juliano T.V.   +3 more
openaire   +3 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

A membrane-based ELISA assay for the herbicide Isoproturon in soil samples [PDF]

, 2012
A membrane based enzyme linked immunosorbent assay (MELISA) for the detection of a common herbicide, isoproturon is described. A heterogeneous competitive ELISA was the format chosen for isoproturon detection.
Baskeyfield, Damian E. H., Damian E. H. Baskeyfield, Magan, Naresh, Naresh Magan, Frank Davis, Davis, Frank, Ibtisam E. Tothill, Tothill, Ibtisam E.   +7 more
core   +1 more source