Results 61 to 70 of about 19,199 (220)

Comprehensive evaluation of the influence of sex differences on composite disease activity indices for rheumatoid arthritis: results from a nationwide observational cohort study

BMC Rheumatology, 2023
Background The effects and their magnitudes of sex on disease activity indices for rheumatoid arthritis are not clear. We aimed to comprehensively evaluate the influence of sex on disease activity indices in the real-world setting using a large ...
Takahiro Nishino, Atsushi Hashimoto, Shigeto Tohma, Toshihiro Matsui   +3 more
doaj   +1 more source

Anti–Carbamylated Fibrinogen Autoantibodies of IgG and IgA Isotypes Contribute to a Better Prognostic Stratification in Very Early Rheumatoid Arthritis: Data From the French National ESPOIR Cohort

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to investigate the prevalence and longitudinal evolution of anti–carbamylated fibrinogen antibodies (ACa‐Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA) and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti–cyclic citrullinated peptide (anti‐CCP ...
Pauline Brevet, Olivia Guérin, Léna Le Goaréguer, Élisa Halbourg, Marie‐Laure Golinski, Sophie Candon, Olivier Boyer, Thierry Lequerré, Thierry Schaeverbeke, Valérie Devauchelle‐Pensec, Olivier Vittecoq, Manuel Fréret   +11 more
wiley   +1 more source

Clinical Characteristics, Comorbidities, and Sex-related Differences Among Smoking and Non-smoking Patients with Rheumatoid Arthritis: A Matched Case–control Study

Saudi Journal of Medicine and Medical Sciences
Background: Smoking may increase levels of pro-inflammatory cytokines, which is an important contributor to rheumatoid arthritis (RA) pathogenesis. Objectives: The aim of this study was to describe the characteristics of RA patients who were smokers ...
Hanan M. Fathi, Samar Tharwat, Khaled El Hadidi, Yousra H. Abdel-Fattah, Marwa A. Amer, Amira M. Ibrahim, Saad M. Elzokm, Hanan M. El-Saadany, Shereen Elwan, Doaa Mosad, Samah Ismail Nasef, Maha E. Ibrahim, Gehad G. Elsehrawy, Suzan S. Al-Adle, Nermeen Samy, Eman F. Mohamed, Enas A. Abdelaleem, Hanan Taha, Faten Ismail, Zahraa I. Selim, Nada M. Gamal, Ahmed Elsaman, Osman Hammam, Reem H. Mohammed, Nevin Hammam, Tamer A. Gheita, On Behalf of the Egyptian College of Rheumatology Rheumatoid Arthritis Study Group   +26 more
doaj   +1 more source

Safety and efficacy of Methotrexate Monotherapy Vs Methotrexate Plus Leflunomide Combination Therapy in Early Active Rheumatoid Arthritis Patients

Medicine Science, 2016
MTX has long been considered as the anchor drug in RA treatment, however given, its high failure rate and the multifactorial nature of the disease, there has been a great interest in developing more powerful and tolerable MTX combination therapies ...
Mariane S. Boshra, Amira S Ahmed, Heba F. Salem, Mohamed N. Abd El Hamid   +3 more
doaj   +1 more source

Glucocorticoid exposure and initiation of SSRIs among patients with rheumatoid arthritis: A nested case–control study in UK primary care

British Journal of Clinical Pharmacology, EarlyView.
Aim The immune system might affect the development of anxiety disorders, though mechanisms remain unclear. This nested case–control study investigates whether use of glucocorticoids, potent immunosuppressants, is associated with SSRI initiation (a proxy for pharmacologically treated mental disorders, predominantly depression and/or anxiety).
Elise J. Heesbeen, Patrick C. Souverein, Eibert R. Heerdink, Elisabeth Y. Bijlsma, Lucianne Groenink   +4 more
wiley   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

DAS28-CRP and its components from the time point of biologics discontinuation to relapse in the 13 cases of late relapse.

DAS28-CRP and its components from the time point of biologics discontinuation to relapse in the 13 cases of late relapse.
Eiji Sakashita (11198546), Katsuya Nagatani (5775395), Seiji Minota (2657893), Hitoshi Endo (413119)   +3 more
core   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Influence of age and gender on the 28-joint Disease Activity Score (DAS28) in rheumatoid arthritis. [PDF]

, 2008
Contains fulltext : 69725.pdf (Publisher’s version ) (Open Access)OBJECTIVES: To investigate the influence of age and gender on the components of the 28-joint Disease Activity Score (DAS28) in patients with rheumatoid arthritis (RA ...
Riel, P.L.C.M. van, Laan, R.F.J.M., Radovits, B.J., Fransen, J.   +3 more
core   +1 more source

Correction of an inflammatory process with an interleukin-1 inhibitor in the combination treatment of secondary osteoarthritis in the presence of comorbid condition

Терапевтический архив, 2015
Aim. To enhance the efficiency of treatment in patients with secondary osteoarthritis (ОА) in the presence of comorbid condition, by using an interleukin-1 inhibitor (IL-1i) and laser therapy (LT). Subjects and methods. A total of 248 patients aged 38 to
I A Starodubtseva, L V Vasilieva, A V Nikitin   +2 more
doaj