Results 171 to 180 of about 54,207 (313)

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Dasatinib is a safe therapy for imatinib-resistant patients with chronic-phase CML [PDF]

, 2007

openalex   +1 more source

Dasatinib and Dysfunction of Platelets [PDF]

Indian Journal of Hematology and Blood Transfusion, 2016
Deba Prasad Dhibar, Vikrant S. Bhar, Kamal Kant Sahu, Pankaj Malhotra, Uday Yanamandra, Subhash Varma   +5 more
openaire   +3 more sources

Chronic myeloid leukemia outcomes according to baseline risk and first‐line treatment in real‐world settings: Data from the Italian Network/CML Campus

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Improved outcome has been reported in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) in sponsored trials. Methods This is a multicenter prospective cohort study of consecutive patients with newly diagnosed chronic phase CML from 19 regions in Italy.
Valentina Giai, Tiziana Rosso, Fausto Castagnetti, Patrizia Pregno, Massimiliano Bonifacio, Isabella Capodanno, Mario Tiribelli, Fabio Stagno, Giovanni Caocci, Antonella Gozzini, Luigiana Luciano, Sara Galimberti, Monica Bocchia, Andrea Patriarca, Giuseppe Lanzarone, Bruno Martino, Anna Guella, Anna Rita Scortechini, Carmen Fava, Claudio Fozza, Simona Sica, Nicola Di Renzo, Pellegrino Musto, Domenico Pastore, Alessandro Maggi, Michele Pizzuti, Lorella Maria Antonia Melillo, Angelo Michele Carella, Giuseppe Tarantini, Anna Mele, Elisabetta Calistri, Maria Rosaria Coppi, Fabio Saccona, Emilia Scalzulli, Beatrice Battaglio, Miriam Iezza, Cinzia Bitetti, Roberto Freilone, Gianantonio Rosti, Francesco Albano, Fabrizio Pane, Giorgina Specchia, Giovannino Ciccone, Giuseppe Saglio, Massimo Breccia   +44 more
wiley   +1 more source

DASATINIB-RELATED CHYLOTHORAX [PDF]

Chest, 2019
Katherine Young, Sunita Kumar, Perry Formanek   +2 more
openaire   +2 more sources

Advancing Design Strategy of PROTACs for Cancer Therapy

MedComm, Volume 6, Issue 7, July 2025.
A comprehensive update on the PROTAC design, and highlighting the role of artificial intelligence in the PROTAC design for cancer therapy. ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics.
Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
wiley   +1 more source

Endoplasmic Reticulum Stress in Cancer

MedComm, Volume 6, Issue 7, July 2025.
Persistent ER stress in tumors activates UPR sensors (IRE1α, PERK, ATF6), driving cancer proliferation, metastasis, immune evasion, and drug resistance. This review explores UPR‐mediated signaling crosstalk, angiogenesis, and therapeutic targeting to develop safer anticancer strategies.
Ruixin Zhou, Wenlong Wang, Baizhao Li, Zhu Li, Juan Huang, Xinying Li   +5 more
wiley   +1 more source

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer [PDF]

, 2008
Qing Chang, Claus Jørgensen, Tony Pawson, David W. Hedley   +3 more
openalex   +1 more source

Efficacy and Mechanism of Bazi Bushen Capsule on Skin Laxity: A Combination of Clinical and Network Pharmacology Study

Journal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.
ABSTRACT Purpose This study aims to explore the mechanism of Bazi Bushen Capsule (BZBS) in treating skin laxity by combining network pharmacology and clinical research. Methods The active ingredients and potential drug targets of BZBS were obtained from TCMSP, TCMBANK, and SuperTCM databases.
Mo Zhao, Tuowei Li, Cuicui Cheng, Jun Mei, Fengqin Xu, Yuanbai Li, Yang Yang, Limin Yang, Jing Li, Xiaojie Zhang, Fangzhou Liu, Zhenhua Jia, Meng Hong   +12 more
wiley   +1 more source

Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib [PDF]

, 2008
Ralf Weichsel, Carolin Dix, Linda Wooldridge, Matthew Clement, Angharad E. Fenton-May, Andrew K. Sewell, J Zezula, Elisabeth Greiner, Emma Gostick, David A. Price, Hermann Einsele, Ruth Seggewiss   +11 more
openalex   +1 more source