Results 61 to 70 of about 54,207 (313)

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

Dasatinib-based 2-step induction for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia

Blood Advances, 2021
Key Points Dasatinib-based 2-step induction resulted in a 100% CR rate with minimal toxicities and 53% MRD negativity. This protocol treatment increased the number of HSCTs in CR1, thereby improving 3-year EFS.
I. Sugiura, N. Doki, T. Hata, R. Cho, Toshiro Ito, Y. Suehiro, Masatsugu Tanaka, S. Kako, M. Matsuda, Hisayuki Yokoyama, Y. Ishikawa, Y. Taniguchi, M. Hagihara, Y. Ozawa, Y. Ueda, Daiki Hirano, T. Sakura, Masaaki Tsuji, T. Kamae, H. Fujita, N. Hiramoto, M. Onoda, S. Fujisawa, Y. Hatta, N. Dobashi, S. Nishiwaki, Y. Atsuta, Y. Kobayashi, F. Hayakawa, S. Ohtake, T. Naoe, Y. Miyazaki   +31 more
semanticscholar   +1 more source

Excellent outcomes of 2G-TKI therapy after imatinib failure in chronic phase CML patients [PDF]

, 2018
open25noSecond-generation tyrosine kinase inhibitors (2G-TKIs) dasatinib and nilotinib produced historical rates of about 50% complete cytogenetic response (CCyR) and about 40% major molecular response (MMR) in chronic myeloid leukaemia (CML) patients ...

core   +1 more source

Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway

Acta Pharmaceutica, 2022
The present study was carried out in human schwannoma cells (HEI-193) to determine the combined anti-cancer effect of curcumin and dasatinib. Cells were treated with curcumin only, dasatinib only, or the combination of curcumin and dasatinib for 24 hours.
Pang Pengfei, Zhang Shirong
doaj   +1 more source

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients [PDF]

, 2016
Background: 8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs).
Aitchison, Michael, Edwards, Joanne, Fraser, Siobhan, Hammond, Rachel, Jones, Robert J., Lim, Zhi, MacDonald, Alasdair I., Oades, Grenville M., Qayyum, Tahir, Roseweir, Antonia K.   +9 more
core   +1 more source

Dasatinib induces apoptosis and autophagy by suppressing the PI3K/Akt/mTOR pathway in bladder cancer cells [PDF]

Investigative and Clinical Urology
Purpose: Bladder cancer is a common genitourinary malignant disease worldwide. Dasatinib is a small molecule inhibitor of Src family kinases. We investigated the anticancer effect and putative molecular mechanisms of dasatinib on T24 and cisplatin ...
Jin-Nyoung Ho, Seok-Soo Byun, Danhyo Kim, Hoyoung Ryu, Sangchul Lee   +4 more
doaj   +1 more source

Reversible ventricular arrythmia induced by dasatinib [PDF]

Clinical Case Reports, 2013
Key Clinical MessageVentricular arrhythmias induced by dasatinib are rare events, but physicians in charge of chronic myeloid leukemia patients should be aware of such potential complications and the need for regular ECG controls during treatment with tyrosine kinase inhibitors.
Spechbach, Hervé, Morel, Philippe, Ing Lorenzini, Kuntheavy, Besson, Marie, Getaz, Laurent, Sunthorn, Henri, Chalandon, Yves   +6 more
openaire   +4 more sources

Enhanced Anticancer Activity of Nanoformulation of Dasatinib against Triple-Negative Breast Cancer

Journal of Personalized Medicine, 2021
Triple negative breast cancer (TNBC) is the most aggressive breast cancer accounting for around 15% of identified breast cancer cases. TNBC lacks human epidermal growth factor receptor 2 (HER2) amplification, is hormone independent estrogen (ER) and ...
Fatemah Bahman, V. Pittalà, M. Haider, K. Greish   +3 more
semanticscholar   +1 more source

Transthyretin familial amyloid polyneuropathy impact on health-related quality of life [PDF]

, 2015
info:eu-repo/semantics ...
Carvalho, M., Coelho, T., Conceicao, I, Costa, J., Ferreira, L. N., Ines, M.   +5 more
core   +2 more sources

Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes

Cancer Medicine, 2016
It has been shown that an increase in cytotoxic lymphocyte counts in the peripheral blood occurs rapidly after taking dasatinib, but the underlying mechanism is not yet elucidated. To investigate the influence of dasatinib on signal transduction pathways,
Noriyoshi Iriyama, Yoshihiro Hatta, Masami Takei   +2 more
doaj   +1 more source