Results 71 to 80 of about 29,286 (231)

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation

Journal of Hematology & Oncology, 2012
Background The BCR-ABL T315I kinase domain mutation is insensitive to dasatinib therapy for Philadelphia-positive acute lymphoid leukemia (Ph + ALL) patients.
Takahashi Naoto, Miura Masatomo, Scott Stuart A, Niioka Takenori, Sawada Kenichi   +4 more
doaj   +1 more source

Dasatinib, an immunomodulator?

, 2010
In this issue of Blood, Kreutzman and colleagues describe the existence of clonal cytotoxic T and NK cells in over 80% (15 of 18) of patients with CML at diagnosis which persisted during treatment with the tyrosine kinase inhibitors, imatinib and ...
Farhad Ravandi
core   +1 more source

Dasatinib Ointment Promotes Healing of Murine Excisional Skin Wound

, 2023
Dasatinib, a tyrosine kinase inhibitor, has been shown to produce anti-inflammatory activity and impair vascular integrity in vivo, including during skin wound healing, potentially promoting the repair process.
Noppawan Phumala Morales, Saovaros Svasti (164396), Pattarawit Rukthong (16260507), Arnatchai Maiuthed, Saovaros Svasti, Surasak Wichaiyo, Pattarawit Rukthong, Arnatchai Maiuthed (16260504), Arman Syah Goli (16260510), Noppawan Phumala Morales (7111760), Arman Syah Goli, Surasak Wichaiyo (8530722)   +11 more
core   +1 more source

Exercise‐Induced Vasculitis in a 12‐Year‐Old Child: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Exercise‐induced vasculitis (EIV), colloquially known as “Disney rash,” is a benign, self‐limited leukocytoclastic vasculitis of the lower extremities triggered by prolonged exertion in warm weather, well‐recognized in adults but underappreciated in children.
Beverly X. Yu, Tyler Sy, Colin M. Kincaid, Maria Gnarra Buethe   +3 more
wiley   +1 more source

Dasatinib and Prednisolone Induction Therapy for a Case of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Dilated Cardiomyopathy Accompanied by Life-Threatening Ventricular Tachycardia

Case Reports in Hematology, 2017
A 56-year-old man being treated for dilated cardiomyopathy presented with epigastralgia. He was diagnosed with ventricular tachycardia and Philadelphia chromosome-positive acute lymphoblastic leukemia. After treating incessant ventricular tachycardia, we
Mitsutaka Nishimoto, Hirohisa Nakamae, Kana Matsumoto, Kunihiko Morita, Yuki Koga, Dai Momose, Masayuki Hino   +6 more
doaj   +1 more source

Dasatinib-induced colitis in a patient with chronic myeloid leukaemia

Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report a woman in her 50s who presented with haematochezia, weight loss and a positive faecal occult blood test. She was being treated
Pillai, Sooraj, Ramaswamy, Pradeep Kakkadasam, Subhaharan, Deloshaan, Gluch, Alexander Edmund   +3 more
core   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1

Frontiers in Cell and Developmental Biology, 2020
Lung cancer is a leading cause cancer-related death with diversity. A promising approach to meet the need for improved cancer treatment is drug repurposing.
Man Zhang, Jie Tian, Rui Wang, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Hanyong Chen, Kangdong Liu, Kangdong Liu, Jung-Hyun Shim, Jung-Hyun Shim, Feng Zhu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee   +17 more
doaj   +1 more source