Results 211 to 220 of about 8,689 (241)

Functional Effects of the DAT1 Polymorphism on EEG Measures in ADHD

Journal of the American Academy of Child & Adolescent Psychiatry, 2003
This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD).A single 10-mg dose of methylphenidate was given in a double-blind, placebo-controlled fashion to children with ADHD who were ...
Sandra K, Loo, Elaine, Specter, Andrew, Smolen, Christian, Hopfer, Peter D, Teale, Martin L, Reite   +5 more
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Occurrence of DAT1 (VNTR) Polymorphism in Individuals with HIV Infection

Current Pharmacogenomics and Personalized Medicine, 2021
Background: Antiretroviral treatment (ART) has been reported to make changes in the functioning of dopaminergic neurons by altering the expression of dopamine active transporter (DAT). ART containing efavirenz drug has been related to show the adverse reactions on the central nervous system (CNS).
HariOm Singh, Sonam Lata
openaire   +1 more source

Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

Journal of the American Academy of Child & Adolescent Psychiatry, 1999
This study attempted to relate the alleles of the D2 (DRD2), D4 (DRD4), and dopamine transporter (DAT1) genes to the behavioral outcome of methylphenidate therapy.African-American children with attention-deficit hyperactivity disorder were treated with methylphenidate in doses not in excess of 60 mg/day. The dosage was increased until behavioral change
B G, Winsberg, D E, Comings
openaire   +2 more sources

Population genetic study of the human dopamine transporter gene (DAT1)

Genetic Epidemiology, 1995
AbstractThe human dopamine transporter gene, DAT1, acts to transport released dopamine into presynaptic terminals of the brain. The possibility that the DAT1 gene plays a role in genetic diseases of the brain has led to studies of DAT1 in several psychiatric and neurological disorders. Previous sequence analysis of DAT1 revealed a 40‐bp repeat in the 3′
L A, Doucette-Stamm, D J, Blakely, J, Tian, S, Mockus, J I, Mao   +4 more
openaire   +2 more sources

DAT1 methylation changes in alcohol-dependent individuals vs. controls

Journal of Psychiatric Research, 2015
The dopaminergic system plays a crucial role in the development of alcohol dependence. Regulation of the extracellular dopamine concentration is driven by dopamine transporter. Both, the expression and function of dopamine transporter, are influenced by chronic alcohol intake.
Andrzej, Jasiewicz, Błażej, Rubiś, Jerzy, Samochowiec, Iwona, Małecka, Aleksandra, Suchanecka, Marcin, Jabłoński, Anna, Grzywacz   +6 more
openaire   +2 more sources

DAT1 gene polymorphism in alcoholism: a family-based association study

Biological Psychiatry, 1999
The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands--and in particular those with severe withdrawal symptoms (seizures and/or delirium)--compared to nonalcoholics.To avoid stratification effects, the family-based association approach of Falk and ...
P, Franke, S G, Schwab, M, Knapp, M, Gänsicke, C, Delmo, P, Zill, M, Trixler, D, Lichtermann, J, Hallmayer, D B, Wildenauer, W, Maier   +10 more
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Potential association of DRD2 and DAT1 genetic variation with heroin dependence

Neuroscience Letters, 2009
The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3'untranslated region VNTR genetic variations with heroin addiction. Genotyping was performed using PCR-based techniques in 530 heroin abusers and 500 controls.
Qiao-Fang, Hou, Sheng-Bin, Li
openaire   +2 more sources

Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations

Neurological Sciences, 2009
The dopamine transporter (DAT1) is a membrane spanning protein that binds the neurotransmitter dopamine and performs re-uptake of dopamine from the synapse into a neuron. The gene encoding DAT1 consists of 15 exons spanning 60 kb on chromosome 5p15.32.
L V K S, Bhaskar, Kumarasamy, Thangaraj, Connie J, Mulligan, Samiksha, Wasnik, Amrita, Nandan, Varun Kumar, Sharma, Vishwas, Sharma, Alla Govardhana, Reddy, Lalji, Singh, Vadlamudi Raghavendra, Rao   +9 more
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DAT1 VNTR Polymorphisms in a European and an African Population: Identification of a New Allele

Human Biology, 2008
Polymorphism frequencies of the dopamine transporter gene (DAT1) hypervariable region have been analyzed in a sample of Italian and Ivory Coast individuals. The 3' untranslated region (UTR) of DAT1 includes a variable number of tandem repeats (VNTR) of a 40-bp monomer, ranging from 3 to 13 repeats in Caucasian and African populations.
Alfredo Santovito, Piero Cervella, Gian Paolo Caviglia   +2 more
exaly   +4 more sources

No association between the DAT1 10‐repeat allele and ADHD in the Iranian population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractAssociation studies between attention‐deficit hyperactivity disorder (ADHD) and the 10‐repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations.
M M, Banoei, T, Majidizadeh, E, Shirazi, N, Moghimi, M, Ghadiri, H, Najmabadi, M, Ohadi   +6 more
openaire   +2 more sources