Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. [PDF]
PLoS ONE, 2014 Dopamine is a catecholamine with multiple physiological functions, playing a key role in nervous system; however its participation in reproductive processes and sperm physiology is controversial.
Javier A Urra +5 more
doaj +9 more sources
The dopamine transporter antiports potassium to increase the uptake of dopamine
Nature Communications, 2022 The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.
Solveig G. Schmidt +9 more
doaj +4 more sources
In Vitro Neurochemical Assessment of Methylphenidate and Its “Legal High” Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis [PDF]
Frontiers in Psychiatry, 2018 3,4-dichloromethylphenidate (3,4-CTMP) and ethylphenidate are new psychoactive substances and analogs of the attention deficit medication methylphenidate. Both drugs have been reported on online user fora to induce effects similar to cocaine.
Colin Davidson +4 more
doaj +5 more sources
PLoS ONE, 2013 ObjectiveBrain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are therapeutically beneficial.
Gene-Jack Wang +12 more
doaj +2 more sources
Novel Ways of Targeting the Dopamine Transporter. [PDF]
Adv NeurobiolDopamine (DA) is an important modulatory neurotransmitter that is involved in daily activities such as movement, memory, and reward-oriented learning of essential behaviors and needs. DA signaling is initiated by the release of DA into the synaptic cleft that will bind to dopamine receptors to mediate the physiological response.
Xu Y, Zeng H, Aggarwal S, Mortensen OV.
europepmc +3 more sources
Dopamine transporter mutant animals: a translational perspective
Journal of Neurogenetics, 2016 Evgeniya V Efimova +2 more
exaly +3 more sources
Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice. [PDF]
Genes Brain BehavHarris E +4 more
europepmc +3 more sources
Dopamine transporter interaction with blockers and transportable substrates: insights from kinetics study [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Competition kinetic analysis was performed to examine the interaction mechanism of the dopamine transporter with dopamine, (S)-amphetamine, and cocaine, which play a central role in drug abuse phenomena connected with the dopaminergic system.
Vladimir Stepanov
doaj +1 more source
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. [PDF]
PLoS Biology, 2005 Brain dopamine is critically involved in movement control, and its deficiency is the primary cause of motor symptoms in Parkinson disease. Here we report development of an animal model of acute severe dopamine deficiency by using mice lacking the ...
Tatyana D Sotnikova +5 more
doaj +2 more sources
Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease. [PDF]
PLoS ONE, 2016 The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter.
D Tomas +5 more
doaj +1 more source