Results 1 to 10 of about 160,722 (119)

Selective vulnerability of dopaminergic neurons in Parkinson’s disease connects PRKN and differential expression of CHCHD2 and GPNMB [PDF]

Cell Death and Disease
The mechanism(s) causing selective vulnerability of dopaminergic neurons in Parkinson’s disease (PD) remain largely elusive. To improve our understanding of mitochondrial involvement and related pathways suggested to play a role in this selective ...
Franca Vulinovic, Arian Hach, Zied Landoulsi, Kerstin Tanzer, Daniel Alvarez-Fischer, Philip Seibler, Christine Klein, Patrick May, Aleksandar Rakovic   +8 more
doaj   +2 more sources

Venoms as an adjunctive therapy for Parkinson’s disease: where are we now and where are we going?

Future Science OA, 2021
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in the aging population. Crucially, neurodegeneration of dopaminergic neurons in PD is associated with chronic inflammation and glial activation.
Parisa Gazerani
doaj   +1 more source

Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores [PDF]

Journal of the Serbian Chemical Society, 2019
A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group
Jevtić Ivana I., Penjišević Jelena Z., Ivanović Milovan D., Kostić-Rajačić Slađana V.   +3 more
doaj   +1 more source

Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis

Advanced Science, 2022
Despite immunosuppression is critical for reducing immune overactivation, existing immunosuppressive agents are largely restricted by low inhibition efficiencies and unpredictable off‐target toxicities.
Juanjuan Li, Weiliang Hou, Sisi Lin, Lu Wang, Chao Pan, Feng Wu, Jinyao Liu   +6 more
doaj   +1 more source

Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence

Pharmaceuticals, 2023
Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress model induced by ...
Mayara Cecile Nascimento Oliveira, Ikla Lima Cavalcante, Alana Natalícia de Araújo, Aline Matilde Ferreira dos Santos, Renata Priscila Barros de Menezes, Chonny Herrera-Acevedo, Natália Ferreira de Sousa, Jailane de Souza Aquino, José Maria Barbosa-Filho, Ricardo Dias de Castro, Reinaldo Nóbrega Almeida, Luciana Scotti, Marcus Tullius Scotti, Mirian Graciela Da Silva Stiebbe Salvadori   +13 more
doaj   +1 more source

Altered expression patterns of inflammation-associated and trophic molecules in substantia nigra and striatum brain samples from Parkinson’s disease, incidental Lewy body disease and normal control cases

Frontiers in Neuroscience, 2016
Evidence of inflammation has been consistently associated with pathology in Parkinson’s disease (PD)-affected brains, and has been suggested as a causative factor.
Douglas Gordon Walker, Lih-Fen eLue, Geidy eSerrano, Thomas Gerald Beach, Lucia eSue, Charles H. Adler, John eCaviness   +6 more
doaj   +1 more source

Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons

Frontiers in Neural Circuits, 2019
Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders.
Alexandra Krol, Violeta G. Lopez-Huerta, Violeta G. Lopez-Huerta, Violeta G. Lopez-Huerta, Taylor E. C. Corey, Karl Deisseroth, Karl Deisseroth, Karl Deisseroth, Jonathan T. Ting, Jonathan T. Ting, Guoping Feng, Guoping Feng   +11 more
doaj   +1 more source

Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion. A possible compensatory mechanism in Parkinson’s disease

Frontiers in Systems Neuroscience, 2011
The onset of Parkinson's disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in
Javier eBlesa, Javier eBlesa, Carlos eJuri, Carlos eJuri, Miguel Ángel eGarcía-Cabezas, Miguel Ángel eGarcía-Cabezas, Rebeca eAdánez, Rebeca eAdánez, Miguel Ángel eSánchez-González, Miguel Ángel eSánchez-González, Carmen eCavada, Carmen eCavada, José A. eObeso, José A. eObeso, José A. eObeso   +14 more
doaj   +1 more source

Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration

Frontiers in Physiology, 2018
Male courtship in Drosophila melanogaster is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons
Shreyas Jois, Yick Bun Chan, Maria Paz Fernandez, Adelaine Kwun-Wai Leung   +3 more
doaj   +1 more source

Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish

Scientific Reports, 2022
Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout vertebrate neural development. Wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in
Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Driever   +4 more
doaj   +1 more source