Results 11 to 20 of about 402,660 (356)

The Cerebellar Dopaminergic System [PDF]

Frontiers in Systems Neuroscience, 2021
In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive functions. Although the cerebellum is not been considered an elective dopaminergic region, studies attributed to it a critical role in dopamine deficit-related ...
Paolo Flace, Paolo Livrea, Gianpaolo Antonio Basile, Diana Galletta, Antonella Bizzoca, Gianfranco Gennarini, Salvatore Bertino, Jacopo Junio Valerio Branca, Massimo Gulisano, Simona Bianconi, Alessia Bramanti, Giuseppe Anastasi   +11 more
doaj   +4 more sources

Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction

International Journal of Molecular Sciences, 2021
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, responsible for the onset of several long-term complications. Recent evidence suggests that cognitive dysfunction represents an emerging complication of DM, but the ...
F. Pignalosa, Antonella Desiderio, Paola Mirra, C. Nigro, Giuseppe Perruolo, L. Ulianich, P. Formisano, F. Beguinot, C. Miele, R. Napoli, F. Fiory   +10 more
semanticscholar   +1 more source

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Nature Methods, 2020
Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (
Fangmiao Sun, Jingheng Zhou, Bing Dai, Tongrui Qian, Jianzhi Zeng, Xuelin Li, Yizhou Zhuo, Yajun Zhang, Yipan Wang, Cheng Qian, Ke Tan, Jiesi Feng, Hui Dong, Dayu Lin, Guohong Cui, Yulong Li   +15 more
semanticscholar   +1 more source

Stress and the dopaminergic reward system

Experimental and Molecular Medicine, 2020
Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system.
J. Baik
semanticscholar   +1 more source

Dopaminergic symptoms in migraine [PDF]

Neurological Sciences, 2013
Migraine pain is often preceded, accompanied and followed by dopaminergic symptoms (premonitory yawning and somnolence, accompanying nausea and vomiting, postdromal somnolence, euphoria and polyuria). After reviewing evidence from pharmacological, biochemical, genetic and animal experimental studies on the relationship between dopamine and migraine ...
Barbanti, Piero, Fofi, L., Aurilia, C., Egeo, G.   +3 more
openaire   +3 more sources

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Nature Communications, 2020
Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
D. Doi, Hiroaki Magotani, Tetsuhiro Kikuchi, Megumi Ikeda, Satoe Hiramatsu, Kenji Yoshida, Naoki Amano, Masaki Nomura, Masafumi Umekage, A. Morizane, J. Takahashi   +10 more
semanticscholar   +1 more source

Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease.

Current Biology, 2020
Current pharmacological treatments for Parkinson's disease (PD) are focused on symptomatic relief, but not on disease modification, based on the strong belief that PD is caused by irreversible dopaminergic neuronal death.
J. Heo, Min-Ho Nam, Hyung Ho Yoon, H. Ryu, S. Jeon, C. J. Lee, Jeongyeon Kim, Y. Hwang, Woojin Won, D. H. Woo, Ji Ae Lee, Hyun-Jung Park, Seonmi Jo, Min Joung Lee, Sunpil Kim, Jeong-eun Shim, D. Jang, Kyoung-In Kim, S. H. Huh, J. Jeong, N. Kowall, Junghee Lee, Hyeonjoo Im, Jong Hyun Park, Bo Ko Jang, Ki Duk Park, H. Lee, Hyogeun Shin, Il-Joo Cho, Eunmi Hwang, Youngsoo Kim, Hye Yun Kim, S. Oh, Seung Eun Lee, S. Paek, J. Yoon, B. Jin, G. Kweon, I. Shim, O. Hwang, J. Lee   +40 more
semanticscholar   +1 more source

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Science Translational Medicine, 2018
Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson’s disease. Systemic inflammasome inhibitor for Parkinson’s disease Brain accumulation of misfolded α-synuclein, progressive loss of ...
R. Gordon, Eduardo A. Albornoz, D. C. Christie, Monica R. Langley, Vinod Kumar, Susanna Mantovani, A. Robertson, M. Butler, D. Rowe, L. O’Neill, A. Kanthasamy, K. Schroder, M. Cooper, T. Woodruff   +13 more
semanticscholar   +1 more source

THE DOPAMINERGIC SYSTEM IN HYPERTENSION

Clinical and Experimental Hypertension, 2001
Dopamine exerts cardiovascular and renal actions mediated through interaction with specific dopamine receptors. Dopamine receptors are cell surface receptors coupled to G-proteins and classified into two main super families based on biochemical, pharmacological and molecular characteristics. The dopamine D1-like receptor super family includes D1 and D5
AMENTA, Francesco, TAYEBATI, Seyed Khosrow, RICCI A., ROSSODIVITA I., AVOLA R.   +4 more
openaire   +3 more sources

Inter-hemispheric asymmetry of nigrostriatal dopaminergic lesion. A possible compensatory mechanism in Parkinson’s disease

Frontiers in Systems Neuroscience, 2011
The onset of Parkinson's disease (PD) is characterized by focal motor features in one body part, which are usually correlated with greater dopaminergic depletion in the contralateral posterior putamen. The role of dopamine (DA) hemispheric differences in
Javier eBlesa, Javier eBlesa, Carlos eJuri, Carlos eJuri, Miguel Ángel eGarcía-Cabezas, Miguel Ángel eGarcía-Cabezas, Rebeca eAdánez, Rebeca eAdánez, Miguel Ángel eSánchez-González, Miguel Ángel eSánchez-González, Carmen eCavada, Carmen eCavada, José A. eObeso, José A. eObeso, José A. eObeso   +14 more
doaj   +1 more source