Results 31 to 40 of about 402,660 (356)
Determinants of dopaminergic neuron loss in Parkinson’s disease
The FEBS Journal, 2018 The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha‐synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis ...
D. Surmeier
semanticscholar +1 more source
Dopaminergic Retinal Cell Loss and Visual Dysfunction in Parkinson Disease
Annals of Neurology, 2020 Considering the demonstrated implication of the retina in Parkinson disease (PD) pathology and the importance of dopaminergic cells in this tissue, we aimed to analyze the state of the dopaminergic amacrine cells and some of their main postsynaptic ...
Isabel Ortuño-Lizarán +6 more
semanticscholar +1 more source
Levosulpiride-induced neurological adverse effects: A prospective study from a tertiary care center
Annals of Indian Academy of Neurology, 2020 Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major ...
Jacob Joe
doaj +1 more source
Molecular Brain, 2021 Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial ...
Mutsumi Yokota +7 more
doaj +1 more source
Discriminating depression, physical and social anhedonia by neurotransmitter related challenge tests [PDF]
, 2016 The aim of this study was to investigate, if anhedonia, a salient component of depression, shows similar response patterns to neurotransmitter challenge tests as depression, and if the two questionnaire based components Physical (PA) and Social (SA ...
Hennig, Juergen, Netter, Petra
core +2 more sources
Cell Death and Differentiation, 2018 Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the reduction of dopamine levels in the striatum.
Eunju Lee +7 more
semanticscholar +1 more source
Electrical and Ca2+ signaling in dendritic spines of substantia nigra dopaminergic neurons
eLife, 2016 Little is known about the density and function of dendritic spines on midbrain dopamine neurons, or the relative contribution of spine and shaft synapses to excitability.
Travis A Hage, Yujie Sun, Zayd M Khaliq
doaj +1 more source
Analytical Cellular Pathology, 2021 An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu +7 more
doaj +1 more source
Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]
, 2011 Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico +6 more
core +2 more sources
The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults [PDF]
, 2016 There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism.
Billino, Jutta +2 more
core +1 more source