Results 51 to 60 of about 402,660 (356)

Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons

Frontiers in Neuroscience, 2014
Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson’s Disease.
John eCave, John eCave, Meng eWang, Meng eWang, Harriet eBaker, Harriet eBaker   +5 more
doaj   +1 more source

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

, 2019
Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood.
Anichtchik, O., Ashery, U., Bar-On, D., Calo’, L., Dalley, J., Giese, A., Griesinger, C., Iovino, M., Leonov, A., Ryazanov, S., Spillantini, M., Wegrzynowicz, M., Xia, J.   +12 more
core   +1 more source

The BE (2)-M17 cell line has a better dopaminergic phenotype than the traditionally used for Parkinson´s research SH-SY5Y, which is mostly serotonergic

IBRO Neuroscience Reports, 2022
SH-SY5Y is a cell line derived from human neuroblastoma. It is one of the most widely used in vitro models to study Parkinson’s disease. Surprisingly, it has been found that it does not develop a dopaminergic phenotype after differentiation, questioning ...
Angel Carvajal-Oliveros, Maritere Uriostegui-Arcos, Mario Zurita, Erika I. Melchy-Perez, Verónica Narváez-Padilla, Enrique Reynaud   +5 more
doaj   +1 more source

The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson's disease [PDF]

, 2015
Published in final edited form as: Mov Disord. 2016 January ; 31(1): 23–38. doi:10.1002/mds.26484.In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of ...
Cronin‐Golomb, Alice, Ellis, Terry D., Otto, Michael W., Reynolds, Gretchen O.   +3 more
core   +1 more source

A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala

Biology of Sex Differences, 2022
Highlights Cell-type specific labeling of VTA-to-BLA dopaminergic axons and synaptic boutons in mice The intensity of dopaminergic innervation in BLA is intermediate between those in PFC and NAC Dopaminergic axon density in BLA and the size of BLA are ...
Matthew T. C. Manion, Erica R. Glasper, Kuan Hong Wang   +2 more
doaj   +1 more source

Abnormal temporal coupling of tactile perception and motor action in Parkinson's disease [PDF]

, 2017
Evidence shows altered somatosensory temporal discrimination threshold (STDT) in Parkinson's disease in comparison to normal subjects. In healthy subjects, movement execution modulates STDT values through mechanisms of sensory gating.
Baione, Viola, Battista, Emanuele, Belvisi, Daniele, Berardelli, Alfredo, Conte, Antonella, Cortese, FRANCESCA NATALIA, Fabbrini, Giovanni, Tartaglia, Matteo, Zhu, Xiao Y.   +8 more
core   +1 more source

Dopaminergic dynamics underlying sex-specific cocaine reward

Nature Communications, 2017
Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent.
E. Calipari, B. Juarez, Carole Morel, D. Walker, M. Cahill, Efrain A. Ribeiro, Ciorana Roman-Ortiz, C. Ramakrishnan, K. Deisseroth, Ming-Hu Han, E. Nestler   +10 more
semanticscholar   +1 more source

Organotypic mouse brain slices: low-cost “ring-inserts” to study cholinergic and dopaminergic neurons with live cell imaging with an emphasis on calcium imaging [PDF]

Biofunctional Materials
Organotypic brain slices preserve the complex 3D cellular structure and are the most potent ex vivo cultures, similar to in vivo conditions. However, their use is limited because of expensive membrane inserts and because the slices cannot be used for ...
Alessa Gern, Patricia Lehmann, Judith Schäfer, Christian Humpel   +3 more
doaj   +1 more source

Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions. [PDF]

, 2010
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with ...
Antonini A, BARONE, PAOLO, BILO, LEONILDA, De Gaspari D, SANTANGELO, Gabriella, Trojano L, VITALE, CARMINE   +6 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source