Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones
Frontiers in Cellular Neuroscience, 2022 Mutations in the dopamine transporter gene (SLC6A3) have been implicated in many human diseases. Among these is the infantile parkinsonism-dystonia known as Dopamine Transporter Deficiency Syndrome (DTDS).
Charles Sutton +12 more
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Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter [PDF]
Structure, 2015 Dopamine transporters (DATs) control neurotransmitter dopamine (DA) homeostasis by reuptake of excess DA, assisted by sodium and chloride ions. The recent resolution of DAT structure (dDAT) from Drosophila permits us for the first time to directly view the sequence of events involved in DA reuptake in human DAT (hDAT) using homology modeling and full ...
Cheng, Mary Hongying, Bahar, Ivet
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Threonine-53 Phosphorylation of Dopamine Transporter Dictates κ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward. [PDF]
J NeurosciDurairaj RV, Ramamoorthy S, Jayanthi LD.
europepmc +3 more sources
Is dopamine transporter gene effective on therapeutic response of methylphenidate in ADHD patients? [PDF]
Reviews in Clinical Medicine, 2015 Attention-deficit/hyperactivity disorder (ADHD) is the most common neuropsychiatric illness, which affects about 5% of children worldwide. An 80% genetic background is responsible for ADHD due to its appearance in familial relationships.
Fatemeh Moharrari, Soheila Barabadian
doaj +3 more sources
Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence. [PDF]
PLoS ONE, 2015 Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing ...
Che-Hung Yen +11 more
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Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia [PDF]
, 2018 Alterations in dopamine neurotransmission are generally associated with diseases such as attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD).
Anna Poleggi +13 more
core +5 more sources
Identification of novel target molecules of l-menthol
Heliyon, 2021 The present study used a binding assay to identify novel target biomolecules of l-menthol ([−]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM l-menthol inhibited the binding of 13 ligands with
Toyoshi Umezu
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The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1 [PDF]
, 2005 Following the current hypothesis that acute schizophrenic psychotic illness is associated with a triatal ‘hyperdopaminergic state’, presynaptic integrity and dopamine transporter (DAT) density in first-episode, neuroleptic-naive schizophrenic patients ...
Abi-Dargham A +13 more
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The dopamine transporter counter-transports potassium to increase the uptake of dopamine
, 2021 Abstract The dopamine transporter (DAT) facilitates dopamine reuptake from the extracellular space, and thereby terminates neurotransmission and refills cellular stores of dopamine. DAT belongs to the neurotransmitter:sodium symporter (NSS) family, which includes similar transporters for serotonin, norepinephrine, and GABA.
Claus Loland +9 more
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Neurobiology of Disease, 2015 The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol
S.T. Masoud +16 more
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