Results 31 to 40 of about 112,428 (350)

Molecular Imaging of the Dopamine Transporter [PDF]

Cells, 2019
Dopamine transporter (DAT) single-photon emission tomography (SPECT) with (123)Ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian syndromes, as it assists with differentiating between Parkinson’s disease (PD) or atypical parkinsonisms and conditions without a presynaptic dopaminergic deficit such as essential tremor ...
Palermo, Giovanni, Ceravolo, Roberto
openaire   +4 more sources

Patient Survey on Satisfaction and Impact of 123I-Ioflupane Dopamine Transporter Imaging. [PDF]

PLoS ONE, 2015
Patients were surveyed to assess the impact of dopamine transporter imaging on diagnostic confidence, change in treatment plan, effect on medication compliance, and subjective well-being.
Matthew F Covington, Scott Sherman, Denise Lewis, Hong Lei, Elizabeth Krupinski, Phillip H Kuo   +5 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Balanced dopamine is critical for pattern completion during associative memory recall. [PDF]

PLoS ONE, 2010
Pattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process.
Fei Li, L Phillip Wang, Xiaoming Shen, Joe Z Tsien   +3 more
doaj   +1 more source

Dopamine Transporter Deficiency Syndrome (DTDS): Expanding the Clinical Phenotype and Precision Medicine Approaches

Cells, 2023
Infantile parkinsonism-dystonia due to dopamine transporter deficiency syndrome (DTDS) is an ultrarare childhood movement disorder caused by biallelic loss-of-function mutations in the SLC6A3 gene.
Joanne Ng, Serena Barral, Simon N. Waddington, Manju A. Kurian   +3 more
doaj   +1 more source

Neurotoxicity induced by mephedrone: an up-to-date review [PDF]

, 2017
BACKGROUND: Mephedrone is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential.
Busardo', FRANCESCO PAOLO, DI LUCA, Alessandro, Mannocchi, Giulio, Marinelli, Enrico, Pacifici, Roberta, Pantano, Flaminia, Tittarelli, Roberta   +6 more
core   +1 more source

Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation [PDF]

, 2012
Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release ...
Frankle, WG, Mason, NS, Moghaddam, B, Muldoon, MF, Narendran, R   +4 more
core   +3 more sources

The binding sites for cocaine and dopamine in the dopamine transporter overlap [PDF]

Nature Neuroscience, 2008
Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT.
Beuming, Thijs, Kniazeff, Julie, Bergmann, Marianne L, Shi, Lei, Gracia, Luis, Raniszewska, Klaudia, Newman, Amy Hauck, Javitch, Jonathan A, Weinstein, Harel, Gether, Ulrik, Løland, Claus Juul   +10 more
openaire   +3 more sources

What mechanisms are responsible for the reuptake of levodopa-derived dopamine in parkinsonian striatum?

Frontiers in Neuroscience, 2016
Levodopa is the most effective medication for motor symptoms in Parkinson’s disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression ...
Haruo Nishijima, Haruo Nishijima, Masahiko Tomiyama, Masahiko Tomiyama   +3 more
doaj   +1 more source

Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]

, 2018
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core   +2 more sources