Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders. [PDF]
, 2014 Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely.
Aman, MG +13 more
core
Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder [PDF]
, 2015 Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood.
Baskin, Britahny M. +2 more
core +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Dopamine-Serotonin Transporter Disease
Pediatric Neurology Briefs, 2013 Investigators at the Hospital for Sick Children, University of Toronto, Canada report 8 children of a consanguineous Saudi Arabian family who had a similar movement disorder, with autosomal recessive inheritance and a mutation in the SLC18A2 gene that ...
J Gordon Millichap
doaj +1 more source
Alcohol addiction: a molecular biology perspective. [PDF]
, 2015 Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero +2 more
core +1 more source
Dopamine Transport in Human Blood
Clinical Chemistry, 1970 Abstract Distribution coefficients were determined for dopamine equilibrated between human blood cells and plasma or its constituents by direct fluorescent reading of this fluorophore recovered in the aqueous phase of a trichloroacetic acid separation. The fluorescence was activated at 280 nm and read at 320nm. Recovery of dopamine added
G, Bryson, F, Bischoff
openaire +2 more sources
Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3 [PDF]
Journal of Nuclear Medicine, 2008 Polymorphisms in the dopamine transporter (DAT) gene SLC6A3 are associated with human striatal DAT expression, but the exact effects on DAT expression are not clear. A variable number of tandem repeats (VNTR) in the 3' untranslated region of the DAT gene was previously investigated in relation to striatal DAT availability, but the results were ...
van de Giessen, Elisabeth M. +5 more
openaire +2 more sources
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Computational Studies on Effects of Cocaine on Fast-paced Dopamine Neurons [PDF]
, 2006 This project has investigated the effects of inhibition of the dopamine transporter on extracellular dopamine when dopaminergic neurons are electrically paced at rates substantially higher than those occurring in the brain.
Choksy, Achint Viral
core +1 more source