Results 41 to 50 of about 112,428 (350)

Reward‐enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention‐deficit/hyperactivity disorder

Neuropsychopharmacology Reports, 2018
Aim Attention‐deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity.
Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +6 more
doaj   +1 more source

Substrate-induced conformational dynamics of the dopamine transporter

Nature Communications, 2019
The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced
Anne Kathrine Nielsen, Ingvar R. Möller, Yong Wang, Søren G. F. Rasmussen, Kresten Lindorff-Larsen, Kasper D. Rand, Claus J. Loland   +6 more
doaj   +1 more source

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse [PDF]

, 2018
Alpha-synuclein is the main component of Lewy bodies, a histopathological finding of Parkinson's disease. Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein and accelerates its aggregation in vitro.
Julku, Ulrika H., Myöhänen, Timo T., Panhelainen, Anne E., Piepponen, T. Petteri, Savolainen, Mari H., Svarcbahs, Reinis, Tammimäki, Anne E., Tiilikainen, Saija E.   +7 more
core   +1 more source

A novel heterocyclic compound CE-104 enhances spatial working memory in the radial arm maze in rats and modulates the dopaminergic system

Frontiers in Behavioral Neuroscience, 2016
Various psychostimulants targeting monoamine neurotransmitter transporters (MAT) have been shown to rescue cognition in patients with neurological disorders and improve cognitive abilities in healthy subjects at low doses.
Yogesh D Aher, Saraswathi eSubramaniyan, Bharanidharan eShanmugasundaram, Ajinkya eSase, Sivaprakasam R Saroja, Marion eHoly, Harald eHoeger, Tetyana eBeryozkina, Harald H Sitte, Johann Jakob Leban, Gert eLubec   +10 more
doaj   +1 more source

Monoaminergic modulation of photoreception in ascidian:evidence for a proto-hypothalamo-retinal territory [PDF]

, 2012
Background : The retina of craniates/vertebrates has been proposed to derive from a photoreceptor prosencephalic territory in ancestral chordates, but the evolutionary origin of the different cell types making the retina is disputed.
Brown, Euan R, Callebert, Jacques, Horie, Takeo, Joly, Jean-Stéphane, Kusakabe, Takehiro G, Razy-Krajka, Florian, Sasakura, Yasunori, Vernier, Philippe   +7 more
core   +5 more sources

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source

The binding sites for benztropines and dopamine in the dopamine transporter overlap [PDF]

Neuropharmacology, 2011
Analogs of benztropines (BZTs) are potent inhibitors of the dopamine transporter (DAT) but are less effective than cocaine as behavioral stimulants. As a result, there have been efforts to evaluate these compounds as leads for potential medication for cocaine addiction.
Heidi, Bisgaard, M Andreas B, Larsen, Sonia, Mazier, Thijs, Beuming, Amy Hauck, Newman, Harel, Weinstein, Lei, Shi, Claus J, Loland, Ulrik, Gether   +8 more
openaire   +3 more sources

Dopaminergic Neurotransmission in Patients With Parkinson's Disease and Impulse Control Disorders: A Systematic Review and Meta-Analysis of PET and SPECT Studies

Frontiers in Neurology, 2018
Background: Around 30% Parkinson's disease (PD) patients develop impulse control disorders (ICDs) to D2/3 dopamine agonists and, to a lesser extent, levodopa.
Alice Martini, Denise Dal Lago, Nicola M. J. Edelstyn, Matteo Salgarello, Fabio Lugoboni, Stefano Tamburin   +5 more
doaj   +1 more source

Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease

Exploration of Neuroprotective Therapy, 2023
Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)].
Bianca Vlcek, Sylvie Dumas, Sara Ekmark-Lewén, Eleonora Rubino, Martin Ingelsson, Åsa Wallén-Mackenzie   +5 more
doaj   +1 more source

Does the catechol-O-methyltransferase (COMT) Val158Met human polymorphism in influence procrastination? [PDF]

, 2017
Genetic studies are enlightening how the expression of several genes influences neuronal activity and all facets of human normal and abnormal behaviour. Among these, a growing body of information shows that a few key genes regulating activity of central ...
Abate, Georgia, Bevilacqua, Arturo, DI NOCERA, Francesco, Ricciardi, Orlando   +3 more
core   +1 more source