Results 121 to 130 of about 47,034,738 (363)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation [PDF]

, 2015
Alexander P. Fields, Edwin H. Rodriguez, Marko Jovanović, Noam Stern‐Ginossar, Brian J. Haas, Philipp Mertins, Raktima Raychowdhury, Nir Hacohen, Steven A. Carr, Nicholas T. Ingolia, Aviv Regev, Jonathan S. Weissman   +11 more
openalex   +1 more source

From Raw Data to FAIR Data: The FAIRification Workflow for Health Research [PDF]

, 2020
Ali Anıl Sınacı, Francisco J. Núñez-Benjumea, Mert Gençtürk, Malte-Levin Jauer, Thomas M. Deserno, Catherine Chronaki, Giorgio Cangioli, Carlos Cavero-Barca, Juan M. Rodríguez-Pérez, Manuel M. Pérez‐Pérez, Gökçe Banu Laleci Ertürkmen, Tony Hernández-Pérez, Eva Méndez, Carlos Luís Parra-Calderón   +13 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Computer note. SIMCOAL: a general coalescent program for the simulation of molecular data in interconnected populations with arbitrary demography [PDF]

, 2000
Laurent Excoffier
openalex   +1 more source

New U(1) Gauge Symmetry of Quarks and Leptons

, 2002
Instead of anchoring the seesaw mechanism with the conventional heavy right-handed neutrino singlet, a small Majorana neutrino mass may be obtained just as well with the addition of a heavy triplet of leptons per family to the minimal standard model of ...
ERNEST MA, Foot R., Geng C. Q., Particle Data Group   +3 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Data, data all around [PDF]

The Lancet Digital Health, 2021
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Using Data in Undergraduate Science Classrooms [PDF]

, 2007
Provides pedagogical insight concerning the skill of using data The resource being annotated is: http://www.dlese.org/dds/catalog_DATA-CLASS-000-000-000-007 ...
Lamont-Doherty Earth Observatory, Columbia University
core