Results 141 to 150 of about 63,638,251 (398)
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Microservices based Linked Data Quality Model for Buildings Energy Management Services [PDF]
Proceedings of Symposium of the Korean Institute of communications
and Information Sciences , 2019.1, 640- 643, 2019 During the production, distribution, and consumption of energy, a large quantity of data is generated. For efficiently using of energy resources other supplementary data such as building information, weather, and environmental data etc. are also collected and used.
arxiv
Informacijske podlage za posamično vrednotenje nepremičnin : Information Required For Single Real Estate Valuation [PDF]
Geodetski Vestnik, 2008 Si: Članek analizira potrebne informacijske podlage za posamično tržno vrednotenje nepremičnin. Republika Slovenija na področju tovrstnih informacijskih podlag nima tradicije.
Albin Rakar, Maruška Šubic Kovač
doaj
Re-Positioning the Law of Theft in View of Recent Developments in ICTS – The Case of South Africa
Potchefstroom Electronic Law Journal, 2016 This article examines the impact of information and communication technologies (ICTs) on the development of the principles of theft. The Roman and South African law of theft forms the basis of such a study.
Mzukisi Niven Njotini
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Toward a view-based data cleaning architecture [PDF]
arXiv, 2019 Big data analysis has become an active area of study with the growth of machine learning techniques. To properly analyze data, it is important to maintain high-quality data. Thus, research on data cleaning is also important. It is difficult to automatically detect and correct inconsistent values for data requiring expert knowledge or data created by ...
arxiv
Application of GIS in ntegrated river basin management, case study of the Blinaja river basin, Kosovo [PDF]
Micro, Macro & Mezzo Geoinformation, 2018 Water is one of the most underlying resources in our life, for human life and for a sustainable development. Integrated managing of water resources asks for a wide base of date concerned with water.
Hazir ÇADRAKU
doaj
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Data Lakes, Clouds and Commons: A Review of Platforms for Analyzing and Sharing Genomic Data [PDF]
arXiv, 2018 Data commons collate data with cloud computing infrastructure and commonly used software services, tools and applications to create biomedical resources for the large-scale management, analysis, harmonization, and sharing of biomedical data. Over the past few years, data commons have been used to analyze, harmonize and share large scale genomics ...
arxiv