Results 131 to 140 of about 50,356,783 (293)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Tree file: RAxML partitioned analysis, combined data, 70% taxon coverage
, 2018 Tree file: RAxML partitioned analysis, combined data, 70% taxon ...
Wood, H (via Mendeley Data) +1 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
SensorsLarge distributed sensor arrays require repeated recalibration as radiation damage, material aging, gain variation, and readout drift alter channel responses.
Saraa Ali +5 more
doaj +1 more source
Tree file: RAxML partitioned analysis, combined data, 50% taxon coverage
, 2018 Tree file: RAxML partitioned analysis, combined data, 50% taxon ...
Wood, H (via Mendeley Data) +1 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Earth, Planets and SpaceHistorical magnetograms are fundamental records for space weather, space climate, and geomagnetism. However, they have rarely been published in searchable or viewable formats, posing a significant barrier to their use by the scientific community.
Shun Imajo +7 more
doaj +1 more source
, 2008 NetCDF (network Common Data Form) is an interface for array-orientated data access and a library that provides an implementation of that interface. Many groups have adopted netCDF as a standard way to represent their scientific data.
Kettleborough, J +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source