Results 171 to 180 of about 25,895,715 (350)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

BioMedStatX - Statistical workflows for reliable biomedical data analysis. [PDF]

MethodsX
Krumm P, Böttcher N, Ottermanns R, Pufe T, Fragoulis A.   +4 more
europepmc   +1 more source

Individual participant data (IPD)-level meta-analysis of randomised controlled trials among dark-skinned populations to estimate the dietary requirement for vitamin D [PDF]

, 2019
Kevin D. Cashman, Christian Ritz
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Longitudinal omics data analysis: approaches and applications. [PDF]

Comput Struct Biotechnol J
Taheriyoun AR, Ross A, Safikhani A, Soudbakhsh D, Rahnavard A.   +4 more
europepmc   +1 more source

The Environmental Problem of Olive Mill Waste Water in Morocco: Data Analysis and Characterization

, 2022
Rabia Benaddi, Abdelillah Bouriqi, Naaila Ouazzani   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Guide to dynamic OCT data analysis. [PDF]

Biomed Opt Express
Heldt N, Monfort T, Morishita R, Schönherr R, Thouvenin O, El-Sadek IA, König P, Hüttmann G, Grieve K, Yasuno Y.   +9 more
europepmc   +1 more source

Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis [PDF]

Awanti Sambarey, Kirk Smith, Carolina H. Chung, Harkirat Singh Arora, Zhenhua Yang, Prachi Agarwal, Sriram Chandrasekaran   +6 more
openalex   +1 more source

Direct medical costs of Parkinson’s disease by Hoehn and Yahr severity in Japan: An analysis of administrative claims data

, 2022
Kenji Baba, Ichiro Naoi, Hidetoshi Shibahara, Sachie Inoue, Hiroshi Aino   +4 more
openalex   +2 more sources