Results 241 to 250 of about 50,356,783 (293)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Integrative Epigenomics: Bioinformatics Strategies for Multi-Omics Data Analysis in Health and Disease. [PDF]

Epigenomes
Baruri S, Batra L, Adhikari S, El-Baz A.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

OPM-FLUX: A Pipeline for OPM MEG Data Analysis

Rakshit A, Ghafari T, Kowalczyk A, Jensen O.   +3 more
europepmc   +1 more source

A seamless workflow for STXM-NEXAFS data analysis using napari: implementation of an ROI spectrum extraction function. [PDF]

MethodsX
Kobayashi K, Yamashita S, Asano M, Wagai R.   +3 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

QproMS: a web application for label-free proteomic data analysis. [PDF]

Bioinform Adv
Bedin F, Cucina G, Martinello G, Rizzieri S, Graziadei A, Cuomo A.   +5 more
europepmc   +1 more source

BRIDGE: an interactive application for multi-omics data analysis, visualization and integration. [PDF]

Bioinformatics
Márquez-Oller D, Pauli A, Fallmann J.
europepmc   +1 more source

Epidemiology and Comorbidity of Vitiligo in Germany: A Claims Data Analysis. [PDF]

Acta Derm Venereol
Klinger T, Augustin M, Baumeister S, Riedel J, Grellmann C, Kamps A, Böhm M, Hagenström K.   +7 more
europepmc   +1 more source