Results 121 to 130 of about 26,844,009 (300)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An auditable no-code platform for building and evaluating hybrid conversational agents

Journal of Information and Telecommunication
While Large Language Models (LLMs) have advanced conversational agents, creating reliable, governable chatbots remains a specialized task, often inaccessible to non-programmers.
Binh Vu, Shashank Barai, Swati Chandna, Mehrdad Jalali   +3 more
doaj   +1 more source

Temporal data analytics

Journal of Biomedical Informatics, 2016
Robert Moskovitch, Fei Wang 0001, Yuval Shahar, George Hripcsak   +3 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Time series modelling and forecasting of mpox incidence and mortality in Nigeria

BMC Infectious Diseases
The World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern (PHEIC) twice, in response to the global outbreak, first in May 2022 and again in August 2024, after a span of 2 years and 3 months.
Emmanuel Afolabi Bakare, Oluwaseun Akinlo Mogbojuri, Dolapo Oluwaseun Oniyelu, Afeez Abidemi, Deborah Oluwatobi Daniel, Idowu Isaac Olasupo, Samuel Abidemi Osikoya, Aaron Onyebuchi Nwana, Ronke Dorcas Olorunfemi, Samson Oluwafemi Olagbami   +9 more
doaj   +1 more source

Cohort profile: the National Congenital Anomaly Registration Dataset in England

BMJ Open
Purpose The National Congenital Anomaly and Rare Disease Registration Service (NCARDRS), part of National Disease Registration Service in National Health Service England, quality assures, curates and analyses individual data on the pregnancies, fetuses ...
Danielle Martin, Sarah Stevens, John Broggio, Chloe Johnson, Kate M Fleming, Ben Wreyford, Sylvia Stoianova, Gabriella Melis, Ewoma Obaro, Jennifer M. Broughan, Kay Randall, Nicholas Aldridge, Donna Gibbard   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Big data analytics and firm performance: Effects of dynamic capabilities

, 2017
S. Wamba, A. Gunasekaran, Shahriar Akter, S. Ren, Rameshwar Dubey, S. Childe   +5 more
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Visualizing health inequality data: guidance for selecting and designing graphs and maps

International Journal for Equity in Health
Several resources and tools have been developed for carrying out health inequality analysis, including the preparation of disaggregated data and calculation of summary measures of health inequality.
Nicole Bergen, Katherine Kirkby, Devaki Nambiar, Anne Schlotheuber, Ahmad Reza Hosseinpoor   +4 more
doaj   +1 more source