Results 121 to 130 of about 21,724,191 (341)

Landscape of official development assistance for nutrition data and information systems. [PDF]

BMJ Glob Health, 2022
Farina A, Rana Y, Flory A, Borces K, Snead C, Heidkamp R.   +5 more
europepmc   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Low-precision feature selection on microarray data: an information theoretic approach. [PDF]

Med Biol Eng Comput, 2022
Morán-Fernández L, Bolón-Canedo V, Alonso-Betanzos A.   +2 more
europepmc   +1 more source

Simplifying NASA Earth Science Data and Information Access Through Natural Language Processing Based Data Analysis and Visualization [PDF]

NASA Earth science data collected from satellites, model assimilation, airborne missions, and field campaigns, are large, complex and evolving. Such characteristics pose great challenges for end users (e.g., Earth science and applied science users ...
Li, Angela, Liu, Zhong, Meyer, David, Pan, Shimei, Wang, Jianwu   +4 more
core   +1 more source

Developing Integrated Waste Management Systems: Information Needs and the Role of Locally Based Data [PDF]

, 2003
No abstract ...
Burnley, Stephen, Frederickson, James, Slater, Rachel, Thomas, Christine   +3 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Graph convolutional network model with a feature compensation module and dual-channel second-order pooling module for multimodal emotion recognition in conversation

Journal of King Saud University: Computer and Information Sciences
Multimodal emotion recognition in conversation (MERC) involves predicting the emotion category of a conversation on the basis of textual, acoustic, and visual modalities.
Xiaocong Tan, Zhengze Gong, Mengkun Gan, Weijie Xie, Wenhui Wang   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Leveraging data and information systems on the sustainable development goals. [PDF]

Int J Med Inform, 2021
Novillo-Ortiz D, Quintana Y, Holmes JH, Borbolla D, De Fatima Marin H.   +4 more
europepmc   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source