Results 261 to 270 of about 21,724,191 (341)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
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International Conferences on Information Technologies and Electrical Engineering, 2020
The country's vital objects that provide data and information are vulnerable to threats. Information in the form of valuable assets needs to be protected from threats and vulnerabilities. Data and information must be guaranteed confidentiality, integrity,
Muhammad Fahrurozi +3 more
semanticscholar +1 more source
The country's vital objects that provide data and information are vulnerable to threats. Information in the form of valuable assets needs to be protected from threats and vulnerabilities. Data and information must be guaranteed confidentiality, integrity,
Muhammad Fahrurozi +3 more
semanticscholar +1 more source
Use of Big Data and Information and Communications Technology in Disasters: An Integrative Review
Disaster Medicine and Public Health Preparedness, 2018Novel approaches to improving disaster response have begun to include the use of big data and information and communication technology (ICT). However, there remains a dearth of literature on the use of these technologies in disasters.
Jeffrey D. Freeman +7 more
semanticscholar +1 more source
2021
The concept of information has been widely deployed within biology. In this chapter I argue that this has largely been done in a colloquial manner, leading to a lack of clarity. In this chapter I argue for a definition of information as the functional relationship between input and system and against the idea that information is something to be ...
openaire +1 more source
The concept of information has been widely deployed within biology. In this chapter I argue that this has largely been done in a colloquial manner, leading to a lack of clarity. In this chapter I argue for a definition of information as the functional relationship between input and system and against the idea that information is something to be ...
openaire +1 more source