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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
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Converting data into information
Journal of Nursing Care Quality, 1994Transforming data into information is a challenge to all professionals working in the quality arena. Reams of data do not provide the answers being sought to challenging questions. Several continuous quality improvement tools, including run charts, control charts, and Pareto charts, can be used to visually display data and provide further ideas for ...
W L, Fields, K A, Siroky
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Converting Data into Information
Hospital Topics, 2012Improving healthcare in the 21st century will depend on how well vast amounts of data are mined. However, converting data contained in multiple hospital and clinical databases into information that can be used for clinical decision support is a complex task.
Beryl C, Vallejo +3 more
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Information Processing & Management, 1984
Abstract Shannon's well-known measure of entropy provides a means of measuring the amount of information in a message—regardless of message content. For the particular case of data statements, Ranganathan's faceted classification scheme provides a means of systematically determining the number of meaningful data that can be constructed from a ...
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Abstract Shannon's well-known measure of entropy provides a means of measuring the amount of information in a message—regardless of message content. For the particular case of data statements, Ranganathan's faceted classification scheme provides a means of systematically determining the number of meaningful data that can be constructed from a ...
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2013
By leveraging Semantic Web technologies, Linked Open Data provides an extensive amount of structured information in a wide variety of domains. Principles of Liked Data facilitate access and re-use of semantic information, both for human and machine consumption. However, information overload due to the availability of a large amount of semantic data, as
Rouzbeh Meymandpour, Joseph G. Davis
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By leveraging Semantic Web technologies, Linked Open Data provides an extensive amount of structured information in a wide variety of domains. Principles of Liked Data facilitate access and re-use of semantic information, both for human and machine consumption. However, information overload due to the availability of a large amount of semantic data, as
Rouzbeh Meymandpour, Joseph G. Davis
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Information theory for data management
Proceedings of the VLDB Endowment, 2009We are awash in data. The explosion in computing power and computing infrastructure allows us to generate multitudes of data, in differing formats, at different scales, and in inter-related areas. Data management is fundamentally about the harnessing of this data to extract information, discovering good representations of the information ...
Divesh Srivastava +1 more
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Presumptions Are Not Data and Data Are Often Not Informative
The American Journal of Bioethics, 2015Jacobs and Arora (2015) argue that infant circumcision is permissible using a “test” of their own invention that “requires application of facts regarding risks and benefits.” Jacobs and Arora's emp...
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Data and information management
1996This chapter deals with data and information management, which is an approach that reserves the use of data for singular pieces of knowledge and information for data that have been connected to other knowledge bases or otherwise purposely processed for use.
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