Results 61 to 70 of about 1,249,061 (355)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Spatiotemporal analysis of phenological metrics on the Qinghai-Tibet Plateau based on multiple vegetation indices

Frontiers in Environmental Science
As global climate change intensifies, understanding the response mechanisms and adaptive capacities of ecosystems to climate change has become a core focus in environmental science.
Tao Chen, Zhu Chen, Guojing Xie
doaj   +1 more source

Diversity and inclusion in digital scholarship and pedagogy: the case of 'The Programming Historian'

Insights: The UKSG Journal, 2019
This article presents several inclusion and diversity policies and strategies for digital scholarship and pedagogy, using 'The Programming Historian' as a case study. By actively supporting and working towards gender diversity, as well as multilingualism,
Anna-Maria Sichani, James Baker, Maria José Afanador Llach, Brandon Walsh   +3 more
doaj   +1 more source

Reuse remix recycle: repurposing archaeological digital data [PDF]

, 2018
Preservation of digital data is predicated on the expectation of its reuse, yet that expectation has never been examined within archaeology. While we have extensive digital archives equipped to share data, evidence of reuse seems paradoxically limited ...
Huggett, Jeremy
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

The screwworm eradication data system archives [PDF]

The archives accumulated during 1 year of operation of the Satellite Temperature-Monitoring System during development of the Screwworm Eradication Data System are reported.
Barnes, C. M., Giddings, L. E., Spaulding, R. R.   +2 more
core   +1 more source

It's Public Knowledge: The National Digital Archive of Datasets [PDF]

, 2004
This article describes the history and development of the National Digital Archive of Datasets, a service run by the University of London Computer Centre for the National Archives of England.
Sleeman, Patricia
core  

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Progress and Problems of Preserving and Providing Access to Qualitative Data for Social Research—The International Picture of an Emerging Culture

Forum: Qualitative Social Research, 2000
In this paper, I hope to offer a global picture of what is happening in the world of qualitative data archiving. Qualidata is in a strong position to be able to offer this insight as it was the world's first initiative to pioneer preservation of ...
Louise Corti
doaj  

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source