Results 51 to 60 of about 588,587 (281)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

LLM-Based Persona-Driven Text Data Augmentation

IEEE Access
Illicit online communication, such as drug-dealing dialogues, is increasingly conducted through covert, context dependent language patterns that evade traditional detection techniques in South Korea.
Hyeon Seong Jeong, Han Kyeong Ko, Soo Yong Park, Taehoon Kim   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Spectral image data aggregation for multisource data augmentation

European Journal of Remote Sensing
Multispectral and hyperspectral images are increasingly popular in different research fields, such as remote sensing, astronomical imaging, or precision agriculture.
R. I. Luca, A. Baicoianu, I. C. Plajer
doaj   +1 more source

Adversarial Data Augmentation on Breast MRI Segmentation

Applied Sciences, 2021
The scarcity of balanced and annotated datasets has been a recurring problem in medical image analysis. Several researchers have tried to fill this gap employing dataset synthesis with adversarial networks (GANs).
João F. Teixeira, Mariana Dias, Eva Batista, Joana Costa, Luís F. Teixeira, Hélder P. Oliveira   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Data augmentation scheme for federated learning with non-IID data

Tongxin xuebao, 2023
To solve the problem that the model accuracy remains low when the data are not independent and identically distributed (non-IID) across different clients in federated learning, a privacy-preserving data augmentation scheme was proposed.Firstly, a data ...
Lingtao TANG, Di WANG, Shengyun LIU
doaj   +2 more sources

Optimizing Rice Plant Disease Classification Using Data Augmentation with GANs on Convolutional Neural Networks

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi
Background: Rice disease classification using CNN models faces challenges due to limited data, particularly in minority classes, and inconsistent image quality, which affect model performance.
Tinuk Agustin, Indrawan Ady Saputro, Mochammad Luthfi Rahmadi   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

SeisAug: A data augmentation python toolkit

Applied Computing and Geosciences
A common limitation in applying any deep learning and machine learning techniques is the limited labelled dataset which can be addressed through Data augmentation (DA). SeisAug is a DA python toolkit to address this challenge in seismological studies. DA.
D. Pragnath, G. Srijayanthi, Santosh Kumar, Sumer Chopra   +3 more
doaj   +1 more source