Results 191 to 200 of about 5,799,187 (309)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Photovoltaic Hydrogen Power-Coupled Polygeneration System for Green Data Center: Energy, Economic, and Environmental Analysis. [PDF]

ACS Omega
Chen Z, Wu X, Tan Z, Hu H, Xiao J.
europepmc   +1 more source

Effective TCP Flow Management Based on Hierarchical Feedback Learning in Complex Data Center Network. [PDF]

Sensors (Basel), 2022
Mizutani K.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

IIoT-Based Remote Monitoring System for Temperature, Current, and Vibration Using PLC and Node-RED in a Data Center Cooling Compressor: A Condition-Based Maintenance Framework. [PDF]

Sensors (Basel)
Pinza Apolo JD, Bravo Robles JL, Dumán Zhicay JL, Cazares Guerrero RX, Albarracin Guarochico WF, Baldeón Egas PF.   +5 more
europepmc   +1 more source

Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descriptive study using Japan medical data center claims database. [PDF]

J Dermatol, 2023
Campos-Alberto E, Hirose T, Napatalung L, Ohyama M.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

GATE Convection Subprogram Data Center, analysis of rawinsonde intercomparison data /

, 1976
Prepared by Center for Experiment Design and Data Analysis."NOAA--S/T 76-2350""November 1976"Mode of access ...
Environmental Research Laboratories (U.S.). Center for Experiment Design and Data Analysis., United States. Environmental Data Service.   +1 more
core  

Global data center expansion and human health: A call for empirical research. [PDF]

Eco Environ Health
Tao Y, Gao P.
europepmc   +1 more source

Financial Data Center Configuration Management System Based on Random Forest Algorithm and Few-Shot Learning. [PDF]

Comput Intell Neurosci, 2022
Li X, Wang L.
europepmc   +1 more source