Results 201 to 210 of about 5,167,888 (260)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
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Proceedings of 5th Asia-Pacific Workshop on Systems, 2014
In this paper, we claim that a vital part of managing a large enterprise data center is creating a model which encompasses all layers of the hardware and software stack, from network links up to application placement and configurations, and moreover that this model must be maintained in real time based on monitoring and trace data.
Zaheer Chothia, Qin Yin, Timothy Roscoe
openaire +1 more source
In this paper, we claim that a vital part of managing a large enterprise data center is creating a model which encompasses all layers of the hardware and software stack, from network links up to application placement and configurations, and moreover that this model must be maintained in real time based on monitoring and trace data.
Zaheer Chothia, Qin Yin, Timothy Roscoe
openaire +1 more source
Proceedings of the 19th ACM Workshop on Hot Topics in Networks, 2020
In enterprises, CDNs, and increasingly in edge computing, most data centers have moderate scale. Recent research has developed designs such as expander graphs that are highly efficient compared to large-scale, 3-tier Clos networks, but moderate-scale data centers need to be constructed with standard hardware and protocols familiar to network engineers,
Vipul Harsh +2 more
openaire +1 more source
In enterprises, CDNs, and increasingly in edge computing, most data centers have moderate scale. Recent research has developed designs such as expander graphs that are highly efficient compared to large-scale, 3-tier Clos networks, but moderate-scale data centers need to be constructed with standard hardware and protocols familiar to network engineers,
Vipul Harsh +2 more
openaire +1 more source